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The Comparative Value of Feline Virology Research: Can Findings from the Feline Lentiviral Vaccine Be Translated to Humans?

1
MRC-University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK
2
Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand
*
Authors to whom correspondence should be addressed.
Academic Editors: Rick Meeker and Jonathan Fogle
Vet. Sci. 2017, 4(1), 7; https://doi.org/10.3390/vetsci4010007
Received: 13 December 2016 / Revised: 17 January 2017 / Accepted: 24 January 2017 / Published: 28 January 2017
(This article belongs to the Special Issue Comparative Studies on HIV and FIV in Animals and Humans)
Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats that shares several similarities with its human counterpart, human immunodeficiency virus (HIV). Their analogies include genomic organization, lymphocyte tropism, viral persistence and induction of immunodeficiency. FIV is the only lentivirus for which a commercial vaccine is registered for prevention in either human or veterinary medicine. This provides a unique opportunity to investigate the mechanisms of protection induced by lentivirus vaccines at the population level and might contribute to the development of efficacious HIV vaccines. As well as having comparative value for vaccine studies, FIV research has shed some light on the relationship between lentiviral tropism and pathogenesis. Recent studies in our laboratory demonstrated that the interaction between FIV and its primary receptor changes as disease progresses, reminiscent of the receptor switch observed as disease progresses in HIV infected individuals. Here we summarise findings illustrating that, in addition to its veterinary significance, FIV has comparative value, providing a useful model to explore lentivirus–host interactions and to examine potential immune correlates of protection against HIV infection. View Full-Text
Keywords: feline immunodeficiency virus; human immunodeficiency virus; vaccine; tropism; comparative study feline immunodeficiency virus; human immunodeficiency virus; vaccine; tropism; comparative study
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MDPI and ACS Style

Hosie, M.J.; Techakriengkrai, N.; Bęczkowski, P.M.; Harris, M.; Logan, N.; Willett, B.J. The Comparative Value of Feline Virology Research: Can Findings from the Feline Lentiviral Vaccine Be Translated to Humans? Vet. Sci. 2017, 4, 7.

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