Intestinal Organoids—Current and Future Applications
1
Institute of Animal Health and Production, Universidade Federal Rural da Amazônia, Avenida Presidente Tancredo Neves 66077-830, Brazil
2
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Patrick Butaye
Vet. Sci. 2016, 3(4), 31; https://doi.org/10.3390/vetsci3040031
Received: 8 August 2016
/
Revised: 19 September 2016
/
Accepted: 19 October 2016
/
Published: 21 October 2016
(This article belongs to the Special Issue Comparative Studies in Embryonic Stem Cell Differentiation across Species)
Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into three-dimensional (3D)-structures. Since organoids can be grown from different species (human, mouse, cat, dog), organs (intestine, kidney, brain, liver), and from patient-derived induced pluripotent stem cells, they create significant prospects for modelling development and diseases, for toxicology and drug discovery studies, and in the field of regenerative medicine. Here, we report on intestinal stem cells, organoid culture, organoid disease modeling, transplantation, specifically covering the current and future uses of this exciting new insight model to the field of veterinary medicine.
View Full-Text
Keywords:
intestinal organoids; dog; practical applications
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Meneses, A.M.C.; Schneeberger, K.; Kruitwagen, H.S.; Penning, L.C.; Van Steenbeek, F.G.; Burgener, I.A.; Spee, B. Intestinal Organoids—Current and Future Applications. Vet. Sci. 2016, 3, 31. https://doi.org/10.3390/vetsci3040031
AMA Style
Meneses AMC, Schneeberger K, Kruitwagen HS, Penning LC, Van Steenbeek FG, Burgener IA, Spee B. Intestinal Organoids—Current and Future Applications. Veterinary Sciences. 2016; 3(4):31. https://doi.org/10.3390/vetsci3040031
Chicago/Turabian StyleMeneses, Andre M.C., Kerstin Schneeberger, Hedwig S. Kruitwagen, Louis C. Penning, Frank G. Van Steenbeek, Iwan A. Burgener, and Bart Spee. 2016. "Intestinal Organoids—Current and Future Applications" Veterinary Sciences 3, no. 4: 31. https://doi.org/10.3390/vetsci3040031
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
