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Progress in Adaptive Immunotherapy for Cancer in Companion Animals: Success on the Path to a Cure

1
DVM/PhD Combined Degree and Comparative Molecular Biosciences Graduate Programs, Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Animal Cancer Care and Research Center, University of Minnesota, St. Paul, MN 55108, USA
2
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Animal Cancer Care and Research Center, Center for Immunology, Masonic Cancer Center, and Stem Cell Institute, University of Minnesota, Minneapolis, MN 55108, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Duncan C. Ferguson and Margarethe Hoenig
Vet. Sci. 2015, 2(4), 363-387; https://doi.org/10.3390/vetsci2040363
Received: 20 August 2015 / Revised: 5 October 2015 / Accepted: 13 October 2015 / Published: 19 October 2015
(This article belongs to the Special Issue Comparative Pathogenesis of Cancers in Animals and Humans)
Harnessing the ability of the immune system to eradicate cancer has been a long-held goal of oncology. Work from the last two decades has finally brought immunotherapy into the forefront for cancer treatment, with demonstrable clinical success for aggressive tumors where other therapies had failed. In this review, we will discuss a range of therapies that are in different stages of clinical or preclinical development for companion animals with cancer, and which share the common objective of eliciting adaptive, anti-tumor immune responses. Even though challenges remain, manipulating the immune system holds significant promise to create durable responses and improve outcomes in companion animals with cancer. Furthermore, what we learn from this process will inform and accelerate development of comparable therapies for human cancer patients. View Full-Text
Keywords: adaptive immunity; T-lymphocytes; antibodies; immunization; Fas ligand; virotherapy adaptive immunity; T-lymphocytes; antibodies; immunization; Fas ligand; virotherapy
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Anderson, K.L.; Modiano, J.F. Progress in Adaptive Immunotherapy for Cancer in Companion Animals: Success on the Path to a Cure. Vet. Sci. 2015, 2, 363-387.

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