Research Progress on the Development of Porcine Reproductive and Respiratory Syndrome Vaccines
Abstract
:Simple Summary
Abstract
1. Introduction
2. MLV Vaccines
Type | Vaccine Strain Name | Approval Time | Source of Vaccine Strains | Company | Vaccine Efficacies | Immune Responses | References |
---|---|---|---|---|---|---|---|
PRRSV-1 | Porcilis PRRS | 2000 | DV | Merck | Minor local reactions | Humoral and cellular immune responses | [34] |
UNISTRAIN PRRS | 2013 | VP- 046 BIS | Hipra | The mean duration of fever was shortened and the number of fever days was significantly lower | Humoral immune response | [35] | |
Ingelvac PRRSFLEX EU | 2015 | 94811 | Boehringer Ingelheim | Increases in Average Daily Weight Gain; reduces the appearance of clinical signs | Humoral and cellular immune responses | [36] | |
ReproCyc PRRS EU | 2015 | 94881 | Boehringer Ingelheim | Reduces viremia | Humoral immune response | [37] | |
Suvaxyn PRRS MLV | 2018 | 96V198 | Zoetis | No local reactions | Humoral and cellular immune responses | [38] | |
PRRSV-2 | Ingelvac PRRS MLV | 1994 | ML (VR2332) | Boehringer Ingelheim | Reduce viremia and lung lesions | Cellular immune responses | [39] |
Fostera PRRS | 2012 | / | Zoetis | Reduces viremia and lung lesions | Humoral and cellular immune responses | [40] | |
PrimePac PRRS | 2014 | / | Merck | Reduces rectal temperatures, clinical respiratory scores, lung lesion scores, and levels of virus load in serum and lung tissue | Cellular immune responses | [41] | |
Prevacent PRRS | 2018 | / | Eli Lilly | / | / | Not reported |
3. Inactivated Vaccine
4. Subunit Vaccine
5. Live Vector Vaccines
6. DNA Vaccines
7. Gene-Deletion Vaccines
8. Synthetic Peptide Vaccines
9. VLP Vaccines
10. Potential Effective Vaccines
11. Summary and Outlook
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Source of Vaccine Strains | Vaccine Strain Name | Vaccine Type | Approval Time |
---|---|---|---|
CH-1a | KV | Inactivated vaccines | 2005 |
VR-2332 | Ingelvac PRRS MLV | MLV | 2005 |
CH-1R | MLV CH-1R | MLV | 2007 |
R98 | MLV R98 | MLV | 2009 |
HP-PRRSV JXA1 | MLV JXA1-R | MLV | 2011 |
HP-PRRSV TJ | MLV TJM-F92 | MLV | 2011 |
HP-PRRSV HuN4 | MLV HuN4-F112 | MLV | 2011 |
HP-PRRSV GD | MLV GDr180 | MLV | 2015 |
Types of Vaccine | Advantage | Disadvantage |
---|---|---|
MLV vaccine | Strong immunogenicity | Low safety; cannot provide complete protection |
Inactivated vaccine | Convenient storage; high security; maternal antibody interference is relatively weak; the vaccine can be used in pigs with weakened immunity | Poor efficacy; multiple vaccinations are needed to strengthen immunity |
Subunit vaccine | No active ingredients; high security; the vaccine can be used in pigs with weakened immunity | High production costs; long development time; low immunogenicity |
Live vector vaccine | Good immune effect; high-concentration expression of antibodies can be achieved after vaccination; a single dose is sufficient to stimulate long-term protection | Vector viruses may also trigger immune responses, thereby reducing vaccine effectiveness; low production efficiency and high cost |
DNA vaccine | The preparation process is simple; the production cycle is short; high security | Low immunogenicity; insufficient resolution of the heterogeneity of PRRSV |
Gene-deletion vaccine | Good safety; long immune period, especially suitable for local vaccination | Difficulty in preparation; high cost |
Synthetic peptide vaccine | Good safety and stability; low production cost | The protective ability of a single linear antigen epitope may not be good for pigs; low immunogenicity |
VLP vaccine | Strong immunogenicity; low immune dose | Difficulty in preparation; high cost |
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Zhang, H.; Luo, Q.; He, Y.; Zheng, Y.; Sha, H.; Li, G.; Kong, W.; Liao, J.; Zhao, M. Research Progress on the Development of Porcine Reproductive and Respiratory Syndrome Vaccines. Vet. Sci. 2023, 10, 491. https://doi.org/10.3390/vetsci10080491
Zhang H, Luo Q, He Y, Zheng Y, Sha H, Li G, Kong W, Liao J, Zhao M. Research Progress on the Development of Porcine Reproductive and Respiratory Syndrome Vaccines. Veterinary Sciences. 2023; 10(8):491. https://doi.org/10.3390/vetsci10080491
Chicago/Turabian StyleZhang, Hang, Qin Luo, Yingxin He, Yajie Zheng, Huiyang Sha, Gan Li, Weili Kong, Jiedan Liao, and Mengmeng Zhao. 2023. "Research Progress on the Development of Porcine Reproductive and Respiratory Syndrome Vaccines" Veterinary Sciences 10, no. 8: 491. https://doi.org/10.3390/vetsci10080491