KITLG Copy Number Germline Variations in Schnauzer Breeds and Their Relevance in Digital Squamous Cell Carcinoma in Black Giant Schnauzers
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Animals and Material
2.1.1. Study 1
2.1.2. Study 2
- (1)
- Control group (n = 11): Blood samples from black giant schnauzers aged >10 years (10–14 years; median 11.5) that remained free of digital SCC until the end of the study were used. There were 4 male dogs, 2 neutered males, 4 females, and 1 neutered female. Six younger dogs without dSCC from study 1 were excluded;
- (2)
- dSCC group: Blood samples from 22 black giant schnauzers aged 6–13 years (median 10) with squamous cell carcinoma of the digit were diagnosed by different pathology laboratories. This group included 7 males, 6 neutered males, 6 females, and 3 neutered female dogs.
2.2. Molecular Genetics
2.3. Statistics
3. Results
3.1. Study 1
3.2. Study 2
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Aupperle-Lellbach, H.; Heidrich, D.; Kehl, A.; Conrad, D.; Brockmann, M.; Törner, K.; Beitzinger, C.; Müller, T. KITLG Copy Number Germline Variations in Schnauzer Breeds and Their Relevance in Digital Squamous Cell Carcinoma in Black Giant Schnauzers. Vet. Sci. 2023, 10, 147. https://doi.org/10.3390/vetsci10020147
Aupperle-Lellbach H, Heidrich D, Kehl A, Conrad D, Brockmann M, Törner K, Beitzinger C, Müller T. KITLG Copy Number Germline Variations in Schnauzer Breeds and Their Relevance in Digital Squamous Cell Carcinoma in Black Giant Schnauzers. Veterinary Sciences. 2023; 10(2):147. https://doi.org/10.3390/vetsci10020147
Chicago/Turabian StyleAupperle-Lellbach, Heike, Daniela Heidrich, Alexandra Kehl, David Conrad, Maria Brockmann, Katrin Törner, Christoph Beitzinger, and Tobias Müller. 2023. "KITLG Copy Number Germline Variations in Schnauzer Breeds and Their Relevance in Digital Squamous Cell Carcinoma in Black Giant Schnauzers" Veterinary Sciences 10, no. 2: 147. https://doi.org/10.3390/vetsci10020147