Patterns of Lymphocytic Infiltrates Can Differentiate Feline Hepatic Lymphoma from Lymphocytic Portal Hepatitis
Abstract
:Simple Summary
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Histopathology
2.3. Immunohistochemistry
2.4. DNA Preparation and PCR
2.5. Case Evaluation
2.6. Statistical Analysis
3. Results
3.1. Clonality
3.2. Case Evaluation
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pattern | Clonality Negative | Clonality Positive | Total |
---|---|---|---|
Pattern 1: Tightly periportal | 15 (83.3%) | 3 (16.7%) | 18 (100%) |
Pattern 2: Periportal and centrilobular | 0 (0%) | 1 (100%) | 1 (100%) |
Pattern 3: Nodular | 0 (0%) | 2 (100%) | 2 (100%) |
Pattern 4: Periportal with sinusoidal extension | 8 (38.1%) | 13 (61.9%) | 21 (100%) |
Pattern 2 and 4: Periportal and centrilobular and sinusoidal extension | 0 (0%) | 2 (100%) | 2 (100%) |
Total | 23 (52.3%) | 21 (47.7%) | 44 (100%) |
Parameter | Flat Prior Model | Weakly Informative Prior Model |
---|---|---|
Pattern sensitivity | 82% (65–96%) | 83% (67–96%) |
Pattern specificity | 77% (54–100%) | 79% (57–100%) |
Clonality sensitivity | 78% (57–100%) | 79% (59–100%) |
Clonality specificity * | 100% (100–100%) | 100% (100–100%) |
Prevalence male | 66% (39–90%) | 65% (40–90%) |
Prevalence female | 54% (30–79%) | 54% (31–78%) |
Clonality Negative | Clonality Positive | |||||
---|---|---|---|---|---|---|
Histology | Cases | n | Percent (95% CI) | Cases | n | Percent (95% CI) |
Bile duct targetting | 23 | 4 | 17.4 (7.0–37.1) | 21 | 5 | 23.8 (10.6–45.1) |
EMH * | 23 | 1 | 4.3 (0.8–21.0) | 21 | 4 | 19.0 (7.7–40.0) |
Fibrosis | 23 | 6 | 26.1 (12.5–46.5) | 21 | 3 | 14.3 (5.0–34.6) |
Lipogranulomas | 23 | 8 | 34.8 (18.8–55.1) | 21 | 5 | 23.8 (10.6–45.1) |
Lymphonodular aggregates | 23 | 13 | 56.5 (36.8–74.4) | 21 | 12 | 57.1 (36.5–75.5) |
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Sebastian, K.; Smedley, R.C.; Bartel, A.; Kiupel, M. Patterns of Lymphocytic Infiltrates Can Differentiate Feline Hepatic Lymphoma from Lymphocytic Portal Hepatitis. Vet. Sci. 2023, 10, 127. https://doi.org/10.3390/vetsci10020127
Sebastian K, Smedley RC, Bartel A, Kiupel M. Patterns of Lymphocytic Infiltrates Can Differentiate Feline Hepatic Lymphoma from Lymphocytic Portal Hepatitis. Veterinary Sciences. 2023; 10(2):127. https://doi.org/10.3390/vetsci10020127
Chicago/Turabian StyleSebastian, Kimberley, Rebecca C. Smedley, Alexander Bartel, and Matti Kiupel. 2023. "Patterns of Lymphocytic Infiltrates Can Differentiate Feline Hepatic Lymphoma from Lymphocytic Portal Hepatitis" Veterinary Sciences 10, no. 2: 127. https://doi.org/10.3390/vetsci10020127