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Microstructural and Metabolic Recovery of Anhedonic Rat Brains: An In Vivo Diffusion MRI and 1H-MRS Approach

1
Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 8000 Aarhus, Denmark
2
Department of Physics and Astronomy, Aarhus University, 8000 Aarhus, Denmark
3
Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR 97239, USA
*
Authors to whom correspondence should be addressed.
Received: 29 June 2018 / Revised: 23 July 2018 / Accepted: 26 July 2018 / Published: 30 July 2018
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Abstract

This article presents longitudinal 1H-MR Spectroscopy (1H-MRS) data from ventral hippocampus and in vivo diffusion MRI (dMRI) data of the brain from control and anhedonic rats. The 1H-MRS and dMRI data were acquired using a 9.4 T preclinical imaging system. Before MRI experiments, animals were exposed to unpredictable chronic mild stress exposure for eight weeks and on the basis of a sucrose consumption test were identified as anhedonic and resilient. An age-matched group of animals, unexposed to the unpredictable chronic mild stress paradigm was considered as control. Data was acquired at the age of 18, 20 and 25 weeks in the anhedonic group and at the age of 18 and 22 weeks in the control group. This multimodal MRI data provides metabolic information of ventral hippocampus and dMRI based microstructural parameters of the brain. View Full-Text
Keywords: diffusion MRI; 1H-MRS; chronic mild stress; kurtosis; hippocampus; amygdala diffusion MRI; 1H-MRS; chronic mild stress; kurtosis; hippocampus; amygdala
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Khan, A.R.; Jespersen, S.N.; Wiborg, O.; Kroenke, C.; Hansen, B. Microstructural and Metabolic Recovery of Anhedonic Rat Brains: An In Vivo Diffusion MRI and 1H-MRS Approach. Data 2018, 3, 29.

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