Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering
1
Biomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
2
Department of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
3
Department of Surgery, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01605, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Traian Chirila
Bioengineering 2021, 8(11), 169; https://doi.org/10.3390/bioengineering8110169
Received: 27 September 2021
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Revised: 26 October 2021
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Accepted: 28 October 2021
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Published: 1 November 2021
(This article belongs to the Special Issue Cell-Biomaterial Interactions: Vol II)
Bone tissue engineering offers versatile solutions to broaden clinical options for treating skeletal injuries. However, the variety of robust bone implants and substitutes remains largely uninvestigated. The advancements in hydrogel scaffolds composed of natural polymeric materials and osteoinductive microparticles have shown to be promising solutions in this field. In this study, gelatin methacrylate (GelMA) hydrogels containing bone meal powder (BP) particles were investigated for their osteoinductive capacity. As natural source of the bone mineral, we expect that BP improves the scaffold’s ability to induce mineralization. We characterized the physical properties of GelMA hydrogels containing various BP concentrations (0, 0.5, 5, and 50 mg/mL). The in vitro cellular studies revealed enhanced mechanical performance and the potential to promote the differentiation of pre-osteoblast cells. The in vivo studies demonstrated both promising biocompatibility and biodegradation properties. Overall, the biological and physical properties of this biomaterial is tunable based on BP concentration in GelMA scaffolds. The findings of this study offer a new composite scaffold for bone tissue engineering.
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Keywords:
hydrogels; scaffolds; bone; photocrosslinking; tissue engineering
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MDPI and ACS Style
Lantigua, D.; Wu, X.; Suvarnapathaki, S.; Nguyen, M.A.; Camci-Unal, G. Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering. Bioengineering 2021, 8, 169. https://doi.org/10.3390/bioengineering8110169
AMA Style
Lantigua D, Wu X, Suvarnapathaki S, Nguyen MA, Camci-Unal G. Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering. Bioengineering. 2021; 8(11):169. https://doi.org/10.3390/bioengineering8110169
Chicago/Turabian StyleLantigua, Darlin, Xinchen Wu, Sanika Suvarnapathaki, Michelle A. Nguyen, and Gulden Camci-Unal. 2021. "Composite Scaffolds from Gelatin and Bone Meal Powder for Tissue Engineering" Bioengineering 8, no. 11: 169. https://doi.org/10.3390/bioengineering8110169
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