A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence
Abstract
:1. Introduction
2. Materials and Methods
2.1. Measurement of Plasma Concentration and Myocardial Fluorescence of Talaporfin Sodium in Canines
2.2. Determination of the Components of Talaparfin Sodium Myocardial Fluorescence Based on Histological Examinations
2.3. Determination of the Compartment Volumes in the Three-Compartment Model
2.4. Three-Compartment Mathematical Modeling of Pharmacokinetics
3. Results
3.1. Determination of Volume Ratios (R1, R2, and R3) and Compartment Volumes (V1, V2, and V3)
3.2. Construction of the Three-Compartment Model Using the Measured Plasma Concentration and Myocardial Fluorescence
4. Discussion
4.1. Methodology of the Constructed Three-Compartment Model for Talaporfin Sodium Using the Myocardial Fluorescence Time History and Volume Ratios Measured from Histological Examinations
4.2. Application of the Three-Compartment Model
4.3. Limitations
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A: How to Obtain a Conversion Constant (Rmyo)
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Uno, Y.; Ogawa, E.; Aiyoshi, E.; Arai, T. A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence. Bioengineering 2019, 6, 1. https://doi.org/10.3390/bioengineering6010001
Uno Y, Ogawa E, Aiyoshi E, Arai T. A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence. Bioengineering. 2019; 6(1):1. https://doi.org/10.3390/bioengineering6010001
Chicago/Turabian StyleUno, Yuko, Emiyu Ogawa, Eitaro Aiyoshi, and Tsunenori Arai. 2019. "A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence" Bioengineering 6, no. 1: 1. https://doi.org/10.3390/bioengineering6010001