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Bioengineering 2018, 5(4), 111;

Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria

Institute of Chemical, Environmental and Bioscience Engineering, Research Area Biochemical Engineering, Technische Universität Wien, 1060 Vienna, Austria
Lackner Ventures and Consulting GmbH, Hofherr Schrantz Gasse 2, 1210 Vienna, Austria
Institute of Industrial Engineering, University of Applied Sciences FH Technikum Wien, Höchstädtplatz 6, 1200 Vienna, Austria
Author to whom correspondence should be addressed.
Received: 22 November 2018 / Revised: 13 December 2018 / Accepted: 15 December 2018 / Published: 18 December 2018
(This article belongs to the Special Issue Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2)
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Polyhydroxyalkanoates (PHAs) are a group of biopolymers produced in various microorganisms as carbon and energy reserve when the main nutrient, necessary for growth, is limited. PHAs are attractive substitutes for conventional petrochemical plastics, as they possess similar material properties, along with biocompatibility and complete biodegradability. The use of PHAs is restricted, mainly due to the high production costs associated with the carbon source used for bacterial fermentation. Cyanobacteria can accumulate PHAs under photoautotrophic growth conditions using CO2 and sunlight. However, the productivity of photoautotrophic PHA production from cyanobacteria is much lower than in the case of heterotrophic bacteria. Great effort has been focused to reduce the cost of PHA production, mainly by the development of optimized strains and more efficient cultivation and recovery processes. Minimization of the PHA production cost can only be achieved by considering the design and a complete analysis of the whole process. With the aim on commercializing PHA, this review will discuss the advances and the challenges associated with the upstream processing of cyanobacterial PHA production, in order to help the design of the most efficient method on the industrial scale. View Full-Text
Keywords: polyhydroxyalkanoate (PHA), bioprocess design; carbon dioxide; cyanobacteria; upstream processing polyhydroxyalkanoate (PHA), bioprocess design; carbon dioxide; cyanobacteria; upstream processing

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Kamravamanesh, D.; Lackner, M.; Herwig, C. Bioprocess Engineering Aspects of Sustainable Polyhydroxyalkanoate Production in Cyanobacteria. Bioengineering 2018, 5, 111.

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