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Bioengineering 2018, 5(3), 56; https://doi.org/10.3390/bioengineering5030056

Conceptual Design of Micro-Bioreactors and Organ-on-Chips for Studies of Cell Cultures

Division of Biotechnology, IFM, Linköping University, 58183 Linköping, Sweden
Received: 9 June 2018 / Revised: 13 July 2018 / Accepted: 14 July 2018 / Published: 19 July 2018
(This article belongs to the Special Issue Advances in Micro-Bioreactor Design for Organ Cell Studies)
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Abstract

Engineering design of microbioreactors (MBRs) and organ-on-chip (OoC) devices can take advantage of established design science theory, in which systematic evaluation of functional concepts and user requirements are analyzed. This is commonly referred to as a conceptual design. This review article compares how common conceptual design principles are applicable to MBR and OoC devices. The complexity of this design, which is exemplified by MBRs for scaled-down cell cultures in bioprocess development and drug testing in OoCs for heart and eye, is discussed and compared with previous design solutions of MBRs and OoCs, from the perspective of how similarities in understanding design from functionality and user purpose perspectives can more efficiently be exploited. The review can serve as a guideline and help the future design of MBR and OoC devices for cell culture studies. View Full-Text
Keywords: biomechatronic design; bioprocess development; toxicity testing; in vitro assay; drug testing; heart-on-a-chip; eye-on-a-chip biomechatronic design; bioprocess development; toxicity testing; in vitro assay; drug testing; heart-on-a-chip; eye-on-a-chip
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Mandenius, C.-F. Conceptual Design of Micro-Bioreactors and Organ-on-Chips for Studies of Cell Cultures. Bioengineering 2018, 5, 56.

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