Bacterial Flora in Screw-Fixed Superstructures with Different Sealing Materials: A Comparative Clinical Trial

Round 1

Reviewer 1 Report

The authors have systematically investigated the effect of Zn-containing GI on the bacterial flora in screw access holes in comparison with some different sealing materials. It is very valauble that the present study further confirmed the potential antibacterial efficacy of Zn-rich sealing materials in vivo. However, it should be concerned that the investigation was only invovled in only 19 patients from age 20 to 80, and the potential different difference between the young and old patients, for example 20-50 and 50-80. It is suggested to provide more information involving the age  bracket before publication. 

Author Response

We express our strong appreciation to the Reviewer for their insightful comments on our paper. We feel the comments have helped us significantly improve the paper.

We have added patient data in Table 2. And we have edited the entire document.

Reviewer 2 Report

Methodological Biases exist

(The Authors must see my remarks)

Comments for author File: Comments.pdf

Author Response

We express our strong appreciation to the Reviewer for their insightful comments on our paper. We feel the comments have helped us significantly improve the paper.

We have responded to the comments in the PDF. In addition, we have highlighted and marked the revised sections of the text. Finally, we also proofread the full text in English.

Author Response File: Author Response.pdf