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Volume 10
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10.3390/bioengineering10091057
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Article

Emprint Microwave Thermoablation System: Bridging Thermal Ablation Efficacy between Human Patients and Porcine Models through Mathematical Correlation

by
Andrea Cafarchio
1,*,
Marcello Iasiello
2,
Maria Chiara Brunese
1,
Giampiero Francica
3,
Aldo Rocca
1 and
Assunta Andreozzi
2
1
Dipartimento di Medicina e Scienze della Salute DIMES, Università degli Studi del Molise, 86100 Campobasso, Italy
2
Dipartimento di Ingegneria Industriale DII, Università degli Studi di Napoli “Federico II”, 80125 Napoli, Italy
3
Interventional Ultrasound Unit, Pineta Grande Hospital, 81030 Castel Volturno, Italy
*
Author to whom correspondence should be addressed.
Bioengineering 2023, 10(9), 1057; https://doi.org/10.3390/bioengineering10091057
Submission received: 31 July 2023 / Revised: 30 August 2023 / Accepted: 6 September 2023 / Published: 7 September 2023
(This article belongs to the Section Regenerative Engineering)
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Abstract

To investigate the in vivo ablation characteristics of a microwave ablation antenna in the livers of humans with tumors, a retrospective analysis of the ablation zones was conducted after applying Emprint microwave ablation systems for treatment. Percutaneous microwave ablations performed between January 2022 and September 2022 were included in this study. Subsequently, immediate post-ablation echography images were subjected to retrospective evaluation to state the long ablated diameter, short ablated diameter, and volume. The calculated ablation lengths and volume indices were then compared between in vivo and ex vivo results obtained from laboratory experiments conducted on porcine liver. The ex vivo data showed a good correlation between energy delivered and both increasing ablated dimensions (both p < 0.001) and volume (p < 0.001). The in vivo data showed a good correlation for dimensions (p = 0.037 and p = 0.019) and a worse correlation for volume (p = 0.142). When comparing ex vivo and in vivo data for higher energies, the ablated volumes grew much more rapidly in ex vivo cases compared to in vivo ones. Finally, a set of correlations to scale ex vivo results with in vivo ones is presented. This phenomenon was likely due to the absence of perfusion, which acts as a cooling system.
Keywords: microwave ablation; hyperthermia; blood perfusion; Emprint; ablation volume microwave ablation; hyperthermia; blood perfusion; Emprint; ablation volume
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MDPI and ACS Style

Cafarchio, A.; Iasiello, M.; Brunese, M.C.; Francica, G.; Rocca, A.; Andreozzi, A. Emprint Microwave Thermoablation System: Bridging Thermal Ablation Efficacy between Human Patients and Porcine Models through Mathematical Correlation. Bioengineering 2023, 10, 1057. https://doi.org/10.3390/bioengineering10091057

AMA Style

Cafarchio A, Iasiello M, Brunese MC, Francica G, Rocca A, Andreozzi A. Emprint Microwave Thermoablation System: Bridging Thermal Ablation Efficacy between Human Patients and Porcine Models through Mathematical Correlation. Bioengineering. 2023; 10(9):1057. https://doi.org/10.3390/bioengineering10091057

Chicago/Turabian Style

Cafarchio, Andrea, Marcello Iasiello, Maria Chiara Brunese, Giampiero Francica, Aldo Rocca, and Assunta Andreozzi. 2023. "Emprint Microwave Thermoablation System: Bridging Thermal Ablation Efficacy between Human Patients and Porcine Models through Mathematical Correlation" Bioengineering 10, no. 9: 1057. https://doi.org/10.3390/bioengineering10091057

APA Style

Cafarchio, A., Iasiello, M., Brunese, M. C., Francica, G., Rocca, A., & Andreozzi, A. (2023). Emprint Microwave Thermoablation System: Bridging Thermal Ablation Efficacy between Human Patients and Porcine Models through Mathematical Correlation. Bioengineering, 10(9), 1057. https://doi.org/10.3390/bioengineering10091057

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