Use of Stromal Intervention and Exogenous Neoantigen Vaccination to Boost Pancreatic Cancer Chemo-Immunotherapy by Nanocarriers
Abstract
:1. Introductory Statement
2. Nano-Enabled Chemo-Immunotherapy in PDAC
2.1. Development of a Dual-Delivery Irinotecan/Lipoxin A4 Liposome to Target the Stroma and Improve PDAC Immunotherapy
2.2. Combined Use of Mutant KRAS Vaccination Approach to Boost the Endogenous Vaccination Response to ICD in PDAC
3. Conclusions and Future Prospects
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Target | Active Agent | Pre-Clinical Model | Mechanism | References |
---|---|---|---|---|
ECM | PEGPH20 | Pancreatic tumor | Depletion of hyaluronic acid | [31,32] |
ECM | Pamrevlumab (FG-3019) | Pancreatic tumor | Reduction in Connective Tissue Growth Factor (CTGF) expression | [33,34] |
ECM | Simtuzumab (GS-6624) | Pancreatic tumor | Lysyl oxidase inhibitor | [35] |
ECM | Losartan | Pancreatic tumor | Angiotensin inhibition reduces stromal collagen and hyaluronan production | [36] |
CAF-cancer cell crosstalk | Resveratrol | Pancreatic tumor | Stromal remodeling by reducing the number of CAFs and leukocytes | [37] |
ECM | Captopril | Pancreatic tumor | TGF-β pathway inhibition | [38] |
ECM | Lipoxin A4 | Pancreatic tumor | TGF-β pathway inhibition | [39] |
CAF-cancer cell crosstalk | Fraxinellone | Pancreatic tumor | TGF-β pathway inhibition | [40] |
CAF-cancer cell crosstalk | Triptolide | Pancreatic tumor | TGF-β pathway inhibition | [41] |
ECM | Cyclopamine | Pancreatic tumor | Hedgehog pathway inhibition | [42,43,44] |
CAF activation | Vismodegib (GDC-0449) | Pancreatic tumor | Hedgehog pathway inhibition | [45] |
CAF-cancer cell crosstalk | Curcumin | Pancreatic tumor | EMT inhibition | [46] |
ECM | Pirfenidone | Pancreatic tumor | MMP-2 reduction | [47] |
Liposomes (0.2 mol% LXA4) | Size (PDI) | Zeta Potential | Loading Capacity | Loading Efficiency |
---|---|---|---|---|
(Units) | (nm) | (mV) | (%) | (%) |
Pre-loading | 88.2 (0.15) | −3.06 ± 2.1 | -- | -- |
Post loading | 76.2 (0.09) | −2.53 ± 3.87 | 28.95 | 82.09 |
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Chattopadhyay, S.; Liao, Y.-P.; Wang, X.; Nel, A.E. Use of Stromal Intervention and Exogenous Neoantigen Vaccination to Boost Pancreatic Cancer Chemo-Immunotherapy by Nanocarriers. Bioengineering 2023, 10, 1205. https://doi.org/10.3390/bioengineering10101205
Chattopadhyay S, Liao Y-P, Wang X, Nel AE. Use of Stromal Intervention and Exogenous Neoantigen Vaccination to Boost Pancreatic Cancer Chemo-Immunotherapy by Nanocarriers. Bioengineering. 2023; 10(10):1205. https://doi.org/10.3390/bioengineering10101205
Chicago/Turabian StyleChattopadhyay, Saborni, Yu-Pei Liao, Xiang Wang, and André E. Nel. 2023. "Use of Stromal Intervention and Exogenous Neoantigen Vaccination to Boost Pancreatic Cancer Chemo-Immunotherapy by Nanocarriers" Bioengineering 10, no. 10: 1205. https://doi.org/10.3390/bioengineering10101205