The Variation of Electrical Pulse Duration Elicits Reliable Network-Mediated Responses of Retinal Ganglion Cells in Normal, Not in Degenerate Primate Retinas
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Infrared (IR) and Spectral-Domain Optical Coherence Tomography (OCT) Image Acquisition and Analysis
2.3. Retinal Preparation and In Vitro Recording
2.4. Data Analysis
3. Results
3.1. MNU Induces Rod Photoreceptor-Specific Retinal Degeneration in Monkey Retinas
3.2. RGCs in RD Monkey Retinas Show Imprecise Spike Response Time with Repeated Electrical Stimulation
3.3. RD Monkey Retinas Need Higher Threshold Charge Density Thane Normal Monkey Retinas
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Cha, S.; Ahn, J.; Kim, S.-W.; Choi, K.-E.; Yoo, Y.; Eom, H.; Shin, D.; Goo, Y.S. The Variation of Electrical Pulse Duration Elicits Reliable Network-Mediated Responses of Retinal Ganglion Cells in Normal, Not in Degenerate Primate Retinas. Bioengineering 2023, 10, 1135. https://doi.org/10.3390/bioengineering10101135
Cha S, Ahn J, Kim S-W, Choi K-E, Yoo Y, Eom H, Shin D, Goo YS. The Variation of Electrical Pulse Duration Elicits Reliable Network-Mediated Responses of Retinal Ganglion Cells in Normal, Not in Degenerate Primate Retinas. Bioengineering. 2023; 10(10):1135. https://doi.org/10.3390/bioengineering10101135
Chicago/Turabian StyleCha, Seongkwang, Jungryul Ahn, Seong-Woo Kim, Kwang-Eon Choi, Yongseok Yoo, Heejong Eom, Donggwan Shin, and Yong Sook Goo. 2023. "The Variation of Electrical Pulse Duration Elicits Reliable Network-Mediated Responses of Retinal Ganglion Cells in Normal, Not in Degenerate Primate Retinas" Bioengineering 10, no. 10: 1135. https://doi.org/10.3390/bioengineering10101135