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Solubility Models for the Recovery of Rosmarinic Acid from Orthosiphon Aristatus Extract Using Solid Phase Extraction

by Cher Haan Lau 1,2 and Lee Suan Chua 1,2,*
1
Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor Bahru, Johor, Malaysia
2
Department of Bioprocess and Polymer Engineering, School of Chemical and Energy Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor Bahru, Johor, Malaysia
*
Author to whom correspondence should be addressed.
ChemEngineering 2019, 3(3), 64; https://doi.org/10.3390/chemengineering3030064
Received: 15 April 2019 / Revised: 21 June 2019 / Accepted: 9 July 2019 / Published: 10 July 2019
Hildebrand and Hansen solubility parameters, and log P value are widely used to determine the solubility of polymers in solvents. The models were used to explain the recovery of phytochemical, rosmarinic acid from Orthosiphon aristatus extract in C18 solid phase extraction (SPE) using the eluent consisting of ethyl acetate and chloroform in the decreasing polarity of solvent system. The experimental recovery of rosmarinic acid appeared to be well explained by the Hansen solubility model. The small difference in the Hansen solubility parameters, particularly for dispersion and hydrogen bonding forces, results in a higher polar solvent system for high rosmarinic acid recovery. The results found that the Hansen solubility model fitted well to the recovery of rosmarinic acid from crude extract with high coefficient of determination (R2 > 0.8), low standard error (4.4%), and p < 0.05. Hildebrand solubility is likely to be the second fit model, whereas log P has poor R2 < 0.7 and higher standard error (7.3%). The Hansen solubility model describes the interaction of solute–solvent in three dimensions (dispersion, polar, and hydrogen bonding forces) which can accurately explain the recovery of rosmarinic acid. Therefore, Hansen solubility can be used to predict the recovery of rosmarinic acid from O. aristatus extract using SPE. View Full-Text
Keywords: Hansen solubility parameter; Hildebrand solubility parameter; log P; rosmarinic acid; solid phase extraction Hansen solubility parameter; Hildebrand solubility parameter; log P; rosmarinic acid; solid phase extraction
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Lau, C.H.; Chua, L.S. Solubility Models for the Recovery of Rosmarinic Acid from Orthosiphon Aristatus Extract Using Solid Phase Extraction. ChemEngineering 2019, 3, 64.

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