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Open AccessArticle

Inpatient Burden of Prurigo Nodularis in the United States

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Department Bloomberg School of Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Author to whom correspondence should be addressed.
Medicines 2019, 6(3), 88;
Received: 29 June 2019 / Revised: 4 August 2019 / Accepted: 8 August 2019 / Published: 11 August 2019
(This article belongs to the Special Issue Pathogenesis and Treatment of Chronic Pruritus)
Background: Although prurigo nodularis (PN) has a significant burden of disease, little is known about its epidemiology and disease burden within the United States. We describe the characteristics of hospitalized patients diagnosed with PN and assess the factors associated with hospitalization. Methods: We performed a cross-sectional study of the 2016 National Inpatient Sample, a representative sample of 20% of hospital discharges nationally. Results: Patients diagnosed with PN accounted for 3.7 inpatient visits per 100,000 discharges nationally in 2016. Patients with PN were more likely to be black (odds ratio (OR) 4.43, 95% CI (3.33–6.08), p < 0.001) or Asian (OR 3.44, 95% CI (1.39–5.08), p = 0.003) compared with white patients. Patients diagnosed with PN had both a longer length of hospital stay (mean ± SD, 6.51 ± 0.37 days vs. 4.62 ± 0.02 days, p < 0.001) and higher cost of care ($14,772 ± $964 vs. $11,728 ± $106, p < 0.001) compared with patients without PN. Patients with PN were significantly more likely to be admitted for HIV complications (OR 78.2, 95% CI (46.4–131.8), p < 0.001). PN contributes to increased inpatient cost of care and length of hospitalization. Conclusions: There are racial disparities associated with hospital admission of patients diagnosed with PN. View Full-Text
Keywords: prurigo nodularis; pruritus; itch; inpatient; disease burden; national inpatient sample prurigo nodularis; pruritus; itch; inpatient; disease burden; national inpatient sample
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Whang, K.A.; Kang, S.; Kwatra, S.G. Inpatient Burden of Prurigo Nodularis in the United States. Medicines 2019, 6, 88.

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