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Phytochemical Modulation of MiRNAs in Colorectal Cancer

Department of Clinical Health Sciences, Doisy College of Health Sciences, Saint Louis University, St. Louis, MO 63104, USA
*
Author to whom correspondence should be addressed.
Medicines 2019, 6(2), 48; https://doi.org/10.3390/medicines6020048
Received: 31 January 2019 / Revised: 28 March 2019 / Accepted: 3 April 2019 / Published: 5 April 2019
(This article belongs to the Special Issue Plant-Derived Medicines and Biological Activity Evaluation)
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Abstract

Colorectal cancer (CRC) is one of the leading causes of death in the United States. Chemotherapy and radiotherapy are some of the most commonly used treatments, but are often associated with severe side effects, and are not entirely curative. It is therefore important to consider other preventative treatment options. Phytochemicals are naturally occurring bioactive compounds which have been shown to play a role in cancer prevention and treatment, especially in regards to a person’s lifestyle and diet. Recent evidence has shown that phytochemicals may exert their chemopreventative effects by targeting micro RNAs (miRNAs), which regulate the downstream expression of tumor suppressors and oncogenes. MiRNAs are small, endogenous, noncoding RNAs that regulate several biological processes through post-translational regulation. The dysregulation of miRNA expression has been shown to be associated with colorectal cancer. In this review, we will summarize and discuss several phytochemicals, which have been shown to exert chemopreventative effects in colorectal cancer by the modulation of miRNA expression. View Full-Text
Keywords: colorectal cancer; phytochemicals; micro RNAs colorectal cancer; phytochemicals; micro RNAs
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Ganapathy, A.; Ezekiel, U. Phytochemical Modulation of MiRNAs in Colorectal Cancer. Medicines 2019, 6, 48.

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