Phytochemical Modulation of MiRNAs in Colorectal Cancer
AbstractColorectal cancer (CRC) is one of the leading causes of death in the United States. Chemotherapy and radiotherapy are some of the most commonly used treatments, but are often associated with severe side effects, and are not entirely curative. It is therefore important to consider other preventative treatment options. Phytochemicals are naturally occurring bioactive compounds which have been shown to play a role in cancer prevention and treatment, especially in regards to a person’s lifestyle and diet. Recent evidence has shown that phytochemicals may exert their chemopreventative effects by targeting micro RNAs (miRNAs), which regulate the downstream expression of tumor suppressors and oncogenes. MiRNAs are small, endogenous, noncoding RNAs that regulate several biological processes through post-translational regulation. The dysregulation of miRNA expression has been shown to be associated with colorectal cancer. In this review, we will summarize and discuss several phytochemicals, which have been shown to exert chemopreventative effects in colorectal cancer by the modulation of miRNA expression. View Full-Text
Share & Cite This Article
Ganapathy, A.; Ezekiel, U. Phytochemical Modulation of MiRNAs in Colorectal Cancer. Medicines 2019, 6, 48.
Ganapathy A, Ezekiel U. Phytochemical Modulation of MiRNAs in Colorectal Cancer. Medicines. 2019; 6(2):48.Chicago/Turabian Style
Ganapathy, Aravinda; Ezekiel, Uthayashanker. 2019. "Phytochemical Modulation of MiRNAs in Colorectal Cancer." Medicines 6, no. 2: 48.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.