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Medicines 2018, 5(3), 66;

Use of References in Responses from Scandinavian Drug Information Centres

Section of Clinical Pharmacology, Laboratory of Clinical Biochemistry, Haukeland University Hospital, 5021 Bergen, Norway
Institute of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, 5021 Bergen, Norway
Clinical Pharmacology, Department of Drug Research, Linköping University, 58183 Linköping, Sweden
Department of Clinical Chemistry & Pharmacology, Odense University Hospital, 5000 Odense, Denmark
Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark
Pharmacy Division, Faculty of Nursing and Health Sciences, Nord University, 7800 Namsos, Norway
Department of Clinical Pharmacology, Bispebjerg University Hospital, 2400 Copenhagen, Denmark
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
Regional Medicines Information and Pharmacovigilance Centre (RELIS Midt-Norge), Department of Clinical Pharmacology, St. Olav University Hospital, 7006 Trondheim, Norway
Author to whom correspondence should be addressed.
Received: 5 June 2018 / Revised: 25 June 2018 / Accepted: 26 June 2018 / Published: 1 July 2018
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Background: The aim of this study was to compare use of references in responses from Scandinavian drug information centres (DICs). Methods: Six different fictitious drug-related queries were sent to each of seven Scandinavian DICs. The six queries concerned adverse effects, pharmacokinetics, pregnancy, complementary medicine, polypharmacy, and breast feeding. References in the responses were categorised into five types of drug information sources: primary (original studies), secondary (reviews), tertiary (drug monographs, handbooks, etc.), DIC database, or personal communication. Results: Two hundred and forty-four references were used in the 42 responses. The mean number of references varied from 3.0 to 10.6 for the six queries. The largest difference between centres with regard to number of references used (range 1–17) was found for the query on complementary medicine. In total, 124 references (50.8%) were tertiary, and only 10 of the 42 responses (23.8%) did not have any tertiary references included. Complementary medicine, breast feeding, and pregnancy were query types associated with relatively frequent use of primary references. Use of DIC database was not uncommon, but personal communications were seldom used. Conclusions: Scandinavian DICs differ substantially in number and type of references to identical drug-related queries. Tertiary sources are mainly preferred irrespective of type of query. View Full-Text
Keywords: adverse effects; breast feeding; complementary medicine; drug information centres; drug information sources; pharmacokinetics; pregnancy; references adverse effects; breast feeding; complementary medicine; drug information centres; drug information sources; pharmacokinetics; pregnancy; references

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Schjøtt, J.; Böttiger, Y.; Damkier, P.; Reppe, L.A.; Kampmann, J.P.; Christensen, H.R.; Spigset, O. Use of References in Responses from Scandinavian Drug Information Centres. Medicines 2018, 5, 66.

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