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A Reassessment of the Marrubium Vulgare L. Herb’s Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons

1
Biomedical Sciences Department, Pharmacy and Pharmaceutical Technology Unit, Faculty of Pharmacy, University of Alcalá, Ctra. de Madrid-Barcelona (Autovía A2) Km. 33,600, 28805 Alcalá de Henares, Madrid, Spain
2
Phytotherapy Faculty, University of Barcelona, Gran Via de les Corts Catalanes, 585, 08007 Barcelona, Spain
3
Faculty of Pharmacy, University of Alcalá, Ctra. de Madrid-Barcelona (Autovía A2) Km. 33,600 28805 Alcalá de Henares, Madrid, Spain
*
Author to whom correspondence should be addressed.
Medicines 2017, 4(3), 57; https://doi.org/10.3390/medicines4030057
Received: 12 July 2017 / Revised: 31 July 2017 / Accepted: 1 August 2017 / Published: 2 August 2017
(This article belongs to the Special Issue Plant Medicines for Clinical Trial)
Despite the wide variety of pharmacological activities described for the Marrubium vulgare L. herb, amazingly, only one clinical trial can be found in scientific literature. It was designed for the evaluation of its antidiabetic activity. Worse, the outcomes of this trial were contradictory to what previous in vivo mice assays had concluded. Therefore, should Marrubium vulgare be ruled out due to its lack of therapeutic potential in diabetes? The authors suggest a reevaluation of the clinical trial methodology to establish valid and final results. View Full-Text
Keywords: Marrubium vulgare L. herb; diabetes mellitus type 2; clinical trial; methodology Marrubium vulgare L. herb; diabetes mellitus type 2; clinical trial; methodology
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Rodríguez Villanueva, J.; Martín Esteban, J.; Rodríguez Villanueva, L. A Reassessment of the Marrubium Vulgare L. Herb’s Potential Role in Diabetes Mellitus Type 2: First Results Guide the Investigation toward New Horizons. Medicines 2017, 4, 57.

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