Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches
School of Engineering, Ulster University, Jordanstown, Northern Ireland BT37 0QB, UK
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Academic Editor: James D. Adams
Medicines 2017, 4(3), 48; https://doi.org/10.3390/medicines4030048
Received: 22 May 2017 / Revised: 28 June 2017 / Accepted: 28 June 2017 / Published: 30 June 2017
The pain relief capabilities of methyl salicylate are well established and a multitude of over-the-counter products populate pharmacy shelves. Over-application of the topical preparation containing the drug, or its accidental ingestion, invariably result in salicylate poisoning and in severe cases can be fatal. The drug has been a regular feature of the US National Poison Database Survey over the past decade and continues to pose a risk to children and adults alike. The aim of the review has been to cast a spotlight on the drug and assess why its use remains problematic, how technology could offer more efficacious delivery regimes, and minimise the possibility of accidental or intentional misuse.
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Keywords:
smart patches; methyl salicylate; toxicity; microneedle; transdermal
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MDPI and ACS Style
Anderson, A.; McConville, A.; Fanthorpe, L.; Davis, J. Salicylate Poisoning Potential of Topical Pain Relief Agents: From Age Old Remedies to Engineered Smart Patches. Medicines 2017, 4, 48.
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