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Medicines, Volume 11, Issue 8

2024 December - 4 articles

Cover Story: Medicines (ISSN 2305-6320) is an international, peer-reviewed, and open-access journal aimed at disseminating cutting-edge research in the field of drug discovery and clinical application. This journal welcomes manuscripts covering a wide range of aspects, including the search for target molecules (e.g., receptors), specificity, side effects, hormesis (bimodal actions), emergence of resistance during long-term administration, potentiation by combinational treatment with more than two drugs, and factors that modify its pharmacological actions (such as sex differences, aging, environmental factors, and physiological fluids). Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Full details must be provided when publishing an experiment so that the results can be reproduced.
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Articles (4)

  • Article
  • Open Access
2 Citations
3,330 Views
9 Pages

Utility of Aprepitant in the Management of Pediatric Patients with Cyclical Vomiting Syndrome

  • Aravind Thavamani,
  • Sindhoosha Malay,
  • Jasmine Khatana,
  • Sujithra Velayuthan and
  • Senthilkumar Sankararaman

11 December 2024

Introduction: Cyclical vomiting syndrome (CVS) is a recurrent debilitating illness characterized by intense episodes of nausea and emesis with widely varied pharmacological management across the country. Aprepitant is now increasingly used in patient...

  • Review
  • Open Access
2 Citations
6,519 Views
14 Pages

Safety Implications of Off-Label Medication Use in Athletes: A Narrative Review

  • Vítor Silva,
  • Ricardo Madeira,
  • João Joaquim and
  • Cristiano Matos

15 November 2024

In recent years, the off-label use of medications in sports has increased significantly, primarily driven by psychological and social factors. Athletes frequently misuse drugs without adequate medical supervision, relying on unreliable sources of inf...

  • Article
  • Open Access
5 Citations
2,592 Views
12 Pages

Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones?

  • Subhas S. Karki,
  • Umashankar Das,
  • Jan Balzarini,
  • Erik De Clercq,
  • Hiroshi Sakagami,
  • Yoshihiro Uesawa,
  • Praveen K. Roayapalley and
  • Jonathan R. Dimmock

30 October 2024

Background: A series of 3,5-benzylidene-4-piperidones, 1a–n, were prepared to evaluate the hypothesis that the placement of different groups in the ortho-location of the aryl rings led to compounds with greater cytotoxic potencies than structur...

(This article belongs to the Topic New Compounds Discovery and Development in Medicine — Advances in Research on Potential Therapeutic Agents and Drug Candidates, 2nd Edition)
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Medicines - ISSN 2305-6320