Developmental Hazard of Environmentally Persistent Free Radicals and Protective Effect of TEMPOL in Zebrafish Model
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. Zebrafish Embryo
2.3. Zebrafish Embryo Assay
2.3.1. Chemical Exposures
2.3.2. Antioxidant Exposures
2.3.3. EPFRs Plus Antioxidant Exposures
2.4. Embryo Photomotor Response Behavior
2.5. Larval Photomotor Response Behavior
2.6. Statistical Analysis
3. Results and Discussion
3.1. Mortality and Morphology Responses to EPFRs
3.2. Neurotoxicity of EPFRs
3.3. Mortality and Morphology Responses to Controls
3.4. Mortality and Morphology Responses to Antioxidants (TEMPOL or PBN)
3.5. Mortality and Morphology Responses to EPFRs Plus Antioxidants
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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A | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
B | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 | 80 |
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D | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 |
E | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 |
F | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 |
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H | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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Guan, X.; Truong, L.; M. Lomnicki, S.; L. Tanguay, R.; A. Cormier, S. Developmental Hazard of Environmentally Persistent Free Radicals and Protective Effect of TEMPOL in Zebrafish Model. Toxics 2021, 9, 12. https://doi.org/10.3390/toxics9010012
Guan X, Truong L, M. Lomnicki S, L. Tanguay R, A. Cormier S. Developmental Hazard of Environmentally Persistent Free Radicals and Protective Effect of TEMPOL in Zebrafish Model. Toxics. 2021; 9(1):12. https://doi.org/10.3390/toxics9010012
Chicago/Turabian StyleGuan, Xia, Lisa Truong, Slawomir M. Lomnicki, Robyn L. Tanguay, and Stephania A. Cormier. 2021. "Developmental Hazard of Environmentally Persistent Free Radicals and Protective Effect of TEMPOL in Zebrafish Model" Toxics 9, no. 1: 12. https://doi.org/10.3390/toxics9010012