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Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity

School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
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Academic Editor: Robert Tanguay
Toxics 2016, 4(3), 19; https://doi.org/10.3390/toxics4030019
Received: 1 July 2016 / Revised: 4 August 2016 / Accepted: 9 August 2016 / Published: 27 August 2016
(This article belongs to the Special Issue Zebrafish as a Model for Assessing Chemical Toxicity)
Neurotransmission is the basis of neuronal communication and is critical for normal brain development, behavior, learning, and memory. Exposure to drugs and chemicals can alter neurotransmission, often through unknown pathways and mechanisms. The zebrafish (Danio rerio) model system is increasingly being used to study the brain and chemical neurotoxicity. In this review, the major neurotransmitter systems, including glutamate, GABA, dopamine, norepinephrine, serotonin, acetylcholine, histamine, and glutamate are surveyed and pathways of synthesis, transport, metabolism, and action are examined. Differences between human and zebrafish neurochemical pathways are highlighted. We also review techniques for evaluating neurological function, including the measurement of neurotransmitter levels, assessment of gene expression through transcriptomic analysis, and the recording of neurobehavior. Finally examples of chemical toxicity studies evaluating alterations in neurotransmitter systems in the zebrafish model are reviewed. View Full-Text
Keywords: acetylcholine; dopamine; GABA; glutamate; neurotoxicology; neurotransmission; neurotransmitters; norepinephrine; serotonin; zebrafish acetylcholine; dopamine; GABA; glutamate; neurotoxicology; neurotransmission; neurotransmitters; norepinephrine; serotonin; zebrafish
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Horzmann, K.A.; Freeman, J.L. Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity. Toxics 2016, 4, 19.

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