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Review

Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy

by 1,†, 1,2,† and 1,*,†
1
Experimental Neurology Unit and Milan Center for Neuroscience, Department of Surgery and Translational Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy
2
PhD Neuroscience Program, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Cheng Wang
Toxics 2015, 3(3), 322-341; https://doi.org/10.3390/toxics3030322
Received: 22 May 2015 / Revised: 28 July 2015 / Accepted: 3 August 2015 / Published: 7 August 2015
(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting side effect of several antineoplastic drugs which significantly reduces patients’ quality of life. Although different molecular mechanisms have been investigated, CIPN pathobiology has not been clarified yet. It has largely been recognized that Dorsal Root Ganglia are the main targets of chemotherapy and that the longest nerves are the most damaged, together with fast axonal transport. Indeed, this bidirectional cargo-specific transport has a pivotal role in neuronal function and its impairment is involved in several neurodegenerative and neurodevelopmental diseases. Literature data demonstrate that, despite different mechanisms of action, all antineoplastic agents impair the axonal trafficking to some extent and the severity of the neuropathy correlates with the degree of damage on this bidirectional transport. In this paper, we will examine the effect of the main old and new chemotherapeutic drug categories on axonal transport, with the aim of clarifying their potential mechanisms of action, and, if possible, of identifying neuroprotective strategies, based on the knowledge of the alterations induced by each drugs. View Full-Text
Keywords: axonal transport; neurotoxicity; peripheral neuropathy axonal transport; neurotoxicity; peripheral neuropathy
MDPI and ACS Style

Nicolini, G.; Monfrini, M.; Scuteri, A. Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy. Toxics 2015, 3, 322-341. https://doi.org/10.3390/toxics3030322

AMA Style

Nicolini G, Monfrini M, Scuteri A. Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy. Toxics. 2015; 3(3):322-341. https://doi.org/10.3390/toxics3030322

Chicago/Turabian Style

Nicolini, Gabriella, Marianna Monfrini, and Arianna Scuteri. 2015. "Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy" Toxics 3, no. 3: 322-341. https://doi.org/10.3390/toxics3030322

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