An Overview of Bortezomib-Induced Neurotoxicity
AbstractThe boronic acid dipeptide bortezomib, able to induce tumor cell death by degradation of key proteins, is the first proteasome inhibitor drug to enter clinical practice. It is employed as first-line treatment in relapsed or resistant multiple myeloma (MM) patients. However, bortezomib often induces a dose-limiting toxicity in the form of painful sensory neuropathy, which can mainly be reduced by subcutaneous administration or dose modification. In this review we focus on the current understanding of the pathophysiological mechanisms of bortezomib-induced neuropathy to allow further studies in animal models and humans, including analysis of clinical and pharmacogenetic aspects, to optimize the treatment regimens. View Full-Text
Share & Cite This Article
Meregalli, C. An Overview of Bortezomib-Induced Neurotoxicity. Toxics 2015, 3, 294-303.
Meregalli C. An Overview of Bortezomib-Induced Neurotoxicity. Toxics. 2015; 3(3):294-303.Chicago/Turabian Style
Meregalli, Cristina. 2015. "An Overview of Bortezomib-Induced Neurotoxicity." Toxics 3, no. 3: 294-303.