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An Overview of Bortezomib-Induced Neurotoxicity

Experimental Neurology Unit, Department of Surgery and Translational Medicine, University of Milan-Bicocca, Via Cadore 48, 20900 Monza (MB), Italy
Academic Editor: Cheng Wang
Toxics 2015, 3(3), 294-303; https://doi.org/10.3390/toxics3030294
Received: 13 May 2015 / Revised: 15 July 2015 / Accepted: 21 July 2015 / Published: 27 July 2015
(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
The boronic acid dipeptide bortezomib, able to induce tumor cell death by degradation of key proteins, is the first proteasome inhibitor drug to enter clinical practice. It is employed as first-line treatment in relapsed or resistant multiple myeloma (MM) patients. However, bortezomib often induces a dose-limiting toxicity in the form of painful sensory neuropathy, which can mainly be reduced by subcutaneous administration or dose modification. In this review we focus on the current understanding of the pathophysiological mechanisms of bortezomib-induced neuropathy to allow further studies in animal models and humans, including analysis of clinical and pharmacogenetic aspects, to optimize the treatment regimens. View Full-Text
Keywords: bortezomib-induced neurotoxicity; multiple myeloma; long-term effects; neuropathic pain bortezomib-induced neurotoxicity; multiple myeloma; long-term effects; neuropathic pain
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Meregalli, C. An Overview of Bortezomib-Induced Neurotoxicity. Toxics 2015, 3, 294-303.

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