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Toxics 2014, 2(3), 377-390;

Short-Term Traffic-Related Exposures and Biomarkers of Nitro-PAH Exposure and Oxidative DNA Damage

Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
Division of Environmental Health Sciences, UC Berkeley School of Public Health, Berkeley, CA 94720, USA
Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, West Roxbury, MA 02132, USA
Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
Nicholas School of the Environment, and Duke Global Health Institute, Duke University, Durham, NC 27708, USA
Channing Division of Network Medicine, Brigham and Women's and Hospital Harvard Medical School, Boston, MA 02115, USA
Author to whom correspondence should be addressed.
Received: 12 May 2014 / Revised: 27 June 2014 / Accepted: 11 July 2014 / Published: 22 July 2014
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Exposure to vehicle exhaust has been associated with cardiac and respiratory disease, lung cancer and greater overall mortality. We investigated whether amino-polycyclic aromatic hydrocarbon (amino-PAH) metabolites of nitro-PAHs could be used as biomarkers of these exposures. Pre- and post-shift urine samples were collected at the beginning and end of a work week from 82 male U.S. trucking industry workers. We used repeated-measures analysis to examine associations of total 1- and 2-aminonaphthalene (1 & 2-AN) and 1-aminopyrene (1-AP) urinary concentrations with microenvironment exposures to particulate matter (PM2.5), elemental and organic carbon and between 1 & 2-AN and 1-AP with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). There was an association between work week mean PM2.5 levels and post-shift 1 & 2-AN (141.8 pg/mL increase (95% CI: 53.3, 230.2) for each IQR increase (5.54 µg/m3) in PM2.5), but no associations with other exposure measures. There was a statistically significant increase in 8-OHdG concentrations with 1 & 2-AN (2.38 µg/mg creatinine (95% CI: 0.19, 4.58) per 242.85 pg/mg creatinine increase in 1 & 2-AN) and suggestive associations with all other exposure measures. Our findings suggest associations between urinary amino-PAHs with vehicle exhaust-related PM2.5, as well as with a biomarker of oxidative DNA damage. View Full-Text
Keywords: traffic emissions; nitro-PAHs; biomarkers; oxidative stress traffic emissions; nitro-PAHs; biomarkers; oxidative stress

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Neophytou, A.M.; Hart, J.E.; Chang, Y.; Zhang, J.; Smith, T.J.; Garshick, E.; Laden, F. Short-Term Traffic-Related Exposures and Biomarkers of Nitro-PAH Exposure and Oxidative DNA Damage. Toxics 2014, 2, 377-390.

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