Reply to Landwehr, K.R.; Larcombe, A.N. Comment on “Karthikeyan et al. Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290”
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References
- Landwehr, K.R.; Larcombe, A.N. Comment on Karthikeyan et al. Concordance Between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290. Toxics 2025, 13, 174. [Google Scholar] [CrossRef]
- Karthikeyan, S.; Breznan, D.; Thomson, E.M.; Blais, E.; Vincent, R.; Kumarathasan, P. Concordance Between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290. [Google Scholar] [CrossRef] [PubMed]
- Landwehr, K.R.; Hillas, J.; Mead-Hunter, R.; Brooks, P.; King, A.; O’Leary, R.A.; Kicic, A.; Mullins, B.J.; Larcombe, A.N. Fuel feedstock determines biodiesel exhaust toxicity in a human airway epithelial cell exposure model. J. Hazard. Mater. 2021, 420, 126637. [Google Scholar] [CrossRef] [PubMed]
- Landwehr, K.R.; Mead-Hunter, R.; O’Leary, R.A.; Kicic, A.; Mullins, B.J.; Larcombe, A.N. Respiratory Health Effects of In Vivo Sub-Chronic Diesel and Biodiesel Exhaust Exposure. Int. J. Mol. Sci. 2023, 24, 5130. [Google Scholar] [CrossRef] [PubMed]
- André, V.; Barraud, C.; Capron, D.; Preterre, D.; Keravec, V.; Vendeville, C.; Cazier, F.; Pottier, D.; Morin, J.P.; Sichel, F. Comparative mutagenicity and genotoxicity of particles and aerosols emitted by the combustion of standard vs. rapeseed methyl ester supplemented bio-diesel fuels: Impact of after treatment devices: Oxidation catalyst and particulate filter. Mutat. Res.-Genet. Toxicol. Environ. Mutagen. 2015, 777, 33–42. [Google Scholar] [CrossRef] [PubMed]
- Jetton, T.L.; Galbraith, O.T.; Peshavaria, M.; Bonney, E.A.; Holmén, B.A.; Fukagawa, N.K. Sex-specific metabolic adaptations from in utero exposure to particulate matter derived from combustion of petrodiesel and biodiesel fuels. Chemosphere 2024, 346, 140480. [Google Scholar] [CrossRef] [PubMed]
- Vogel, C.F.A.; Kado, S.Y.; Kobayashi, R.; Liu, X.; Wong, P.; Na, K.; Durbin, T.; Okamoto, R.A.; Kado, N.Y. Inflammatory marker and aryl hydrocarbon receptor-dependent responses in human macrophages exposed to emissions from biodiesel fuels. Chemosphere 2019, 220, 993–1002. [Google Scholar] [CrossRef] [PubMed]
- Karthikeyan, S.; Thomson, E.M.; Kumarathasan, P.; Guénette, J.; Rosenblatt, D.; Chan, T.; Rideout, G.; Vincent, R. Nitrogen dioxide and ultrafine particles dominate the biological effects of inhaled diesel exhaust treated by a catalyzed diesel particulate filter. Toxicol. Sci. 2013, 135, 437–450. [Google Scholar] [CrossRef] [PubMed]
- Guénette, J.; Breznan, D.; Thomson, E.M. Establishing an air-liquid interface exposure system for exposure of lung cells to gases. Inhal. Toxicol. 2022, 34, 80–89. [Google Scholar] [CrossRef] [PubMed]
- Thomson, E.M.; Breznan, D.; Karthikeyan, S.; MacKinnon-Roy, C.; Vuong, N.Q.; Dabek-Zlotorzynska, E.; Celo, V.; Charland, J.P.; Kumarathasan, P.; Brook, J.R.; et al. Contrasting biological potency of particulate matter collected at sites impacted by distinct industrial sources. Part. Fibre Toxicol. 2016, 13, 65. [Google Scholar] [CrossRef] [PubMed]
- Thomson, E.M.; Breznan, D.; Karthikeyan, S.; MacKinnon-Roy, C.; Charland, J.P.; Dabek-Zlotorzynska, E.; Celo, V.; Kumarathasan, P.; Brook, J.R.; Vincent, R. Cytotoxic and inflammatory potential of size-fractionated particulate matter collected repeatedly within a small urban area. Part. Fibre Toxicol. 2015, 12, 24. [Google Scholar] [CrossRef] [PubMed]
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Karthikeyan, S.; Breznan, D.; Thomson, E.M.; Blais, E.; Kumarathasan, P. Reply to Landwehr, K.R.; Larcombe, A.N. Comment on “Karthikeyan et al. Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290”. Toxics 2025, 13, 186. https://doi.org/10.3390/toxics13030186
Karthikeyan S, Breznan D, Thomson EM, Blais E, Kumarathasan P. Reply to Landwehr, K.R.; Larcombe, A.N. Comment on “Karthikeyan et al. Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290”. Toxics. 2025; 13(3):186. https://doi.org/10.3390/toxics13030186
Chicago/Turabian StyleKarthikeyan, Subramanian, Dalibor Breznan, Errol M. Thomson, Erica Blais, and Premkumari Kumarathasan. 2025. "Reply to Landwehr, K.R.; Larcombe, A.N. Comment on “Karthikeyan et al. Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290”" Toxics 13, no. 3: 186. https://doi.org/10.3390/toxics13030186
APA StyleKarthikeyan, S., Breznan, D., Thomson, E. M., Blais, E., & Kumarathasan, P. (2025). Reply to Landwehr, K.R.; Larcombe, A.N. Comment on “Karthikeyan et al. Concordance between In Vitro and In Vivo Relative Toxic Potencies of Diesel Exhaust Particles from Different Biodiesel Blends. Toxics 2024, 12, 290”. Toxics, 13(3), 186. https://doi.org/10.3390/toxics13030186