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Article

Differential Expression of AhR in Peripheral Mononuclear Cells in Response to Exposure to Polycyclic Aromatic Hydrocarbons in Mexican Women

by
José Antonio Varela-Silva
1,
Miguel Ernesto Martínez-Leija
1,
Sandra Teresa Orta-García
2,
Ivan Nelinho Pérez-Maldonado
2,
Jesús Adrián López
3,
Hiram Hernández-López
4,
Roberto González-Amaro
5,
Emma S. Calderón-Aranda
6,
Diana Patricia Portales-Pérez
3 and
Mariana Salgado-Bustamante
1,*
1
Biochemistry Department, and Immunology, Department of Faculty of Medicine, UASLP, San Luis Potosí 78000, Mexico
2
Laboratory of Molecular Toxicology, Centro de Investigación Aplicada en, Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la, Ciencia y la Tecnología (CIACYT), UASLP, San Luis Potosí 78000, Mexico
3
Laboratorio de microRNAs y Cáncer, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacatecas, Zacatecas 98066, Mexico
4
Academic Unit of Chemistry Sciences, Universidad Autónoma de Zacatecas, Zacatecas 98606, Mexico
5
Laboratory of Immunology Cellular and molecular, Faculty of Chemistry, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78000, Mexico
6
Toxicology Department, Centro de Investigación y Estudios Avanzados, IPN, México City 07360, Mexico
*
Author to whom correspondence should be addressed.
Toxics 2023, 11(1), 28; https://doi.org/10.3390/toxics11010028
Submission received: 12 November 2022 / Revised: 18 December 2022 / Accepted: 22 December 2022 / Published: 28 December 2022
(This article belongs to the Special Issue Environmental Exposure to Toxic Chemicals and Human Health)
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Abstract

The exposure to air pollutants causes significant damage to health, and inefficient cooking and heating practices produce high levels of household air pollution, including a wide range of health-damaging pollutants such as fine particles, carbon monoxide and PAHs. The exposure to PAHs has been associated with the development of neoplastic processes, asthma, genotoxicity, altered neurodevelopment and inflammation. The effects on the induction of proinflammatory cytokines are attributed to the activation of AhR. However, the molecular mechanisms by which the PAHs produce proinflammatory effects are unknown. This study was performed on a group of 41 Mexican women from two rural communities who had stoves inside their houses, used wood as biomass fuel, and, thus, were vulnerable. According to the urinary 1-OHP concentration, the samples were stratified into two groups for determination of the levels of TNF-α, AhR, CYP1B1, miR-125b and miR-155 expression. Our results showed that the CYP1B1, TNF-α, miR-125b and miR-155 expression levels were not statistically different between women with the lowest and highest levels of 1-OHP. Interestingly, high levels of PAHs promoted augmented expression of AhR, which is a protein involved in the modulation of inflammatory pathways in vivo, suggesting that cell signaling of AhR may be implicated in several pathogenesis processes.
Keywords: pollutants; women exposure; microRNAs; PAHs pollutants; women exposure; microRNAs; PAHs

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MDPI and ACS Style

Varela-Silva, J.A.; Martínez-Leija, M.E.; Orta-García, S.T.; Pérez-Maldonado, I.N.; López, J.A.; Hernández-López, H.; González-Amaro, R.; Calderón-Aranda, E.S.; Portales-Pérez, D.P.; Salgado-Bustamante, M. Differential Expression of AhR in Peripheral Mononuclear Cells in Response to Exposure to Polycyclic Aromatic Hydrocarbons in Mexican Women. Toxics 2023, 11, 28. https://doi.org/10.3390/toxics11010028

AMA Style

Varela-Silva JA, Martínez-Leija ME, Orta-García ST, Pérez-Maldonado IN, López JA, Hernández-López H, González-Amaro R, Calderón-Aranda ES, Portales-Pérez DP, Salgado-Bustamante M. Differential Expression of AhR in Peripheral Mononuclear Cells in Response to Exposure to Polycyclic Aromatic Hydrocarbons in Mexican Women. Toxics. 2023; 11(1):28. https://doi.org/10.3390/toxics11010028

Chicago/Turabian Style

Varela-Silva, José Antonio, Miguel Ernesto Martínez-Leija, Sandra Teresa Orta-García, Ivan Nelinho Pérez-Maldonado, Jesús Adrián López, Hiram Hernández-López, Roberto González-Amaro, Emma S. Calderón-Aranda, Diana Patricia Portales-Pérez, and Mariana Salgado-Bustamante. 2023. "Differential Expression of AhR in Peripheral Mononuclear Cells in Response to Exposure to Polycyclic Aromatic Hydrocarbons in Mexican Women" Toxics 11, no. 1: 28. https://doi.org/10.3390/toxics11010028

APA Style

Varela-Silva, J. A., Martínez-Leija, M. E., Orta-García, S. T., Pérez-Maldonado, I. N., López, J. A., Hernández-López, H., González-Amaro, R., Calderón-Aranda, E. S., Portales-Pérez, D. P., & Salgado-Bustamante, M. (2023). Differential Expression of AhR in Peripheral Mononuclear Cells in Response to Exposure to Polycyclic Aromatic Hydrocarbons in Mexican Women. Toxics, 11(1), 28. https://doi.org/10.3390/toxics11010028

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