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Article

A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

1
Women’s Reproductive Health Research Center, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, 1161 21st Ave S, MCN B-1100, Nashville, TN 37232, USA
2
Department of Microbiology, Immunology and Physiology, Meharry Medical College, Nashville, TN 37208, USA
3
Department of Pharmacology, Vanderbilt University, Nashville, TN 37208, USA
4
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37208, USA
5
VA Tennessee Valley Healthcare System, Nashville, TN 37208, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Kimberly Keil Stietz, Tracie Baker and Jessica Plavicki
Received: 12 October 2021 / Revised: 13 December 2021 / Accepted: 22 December 2021 / Published: 27 December 2021
(This article belongs to the Special Issue Developmental Exposure to Environmental Contaminants)
New bronchopulmonary dysplasia is a developmental lung disease associated with placental dysfunction and impaired alveolarization. Risk factors for new BPD include prematurity, delayed postnatal growth, the dysregulation of epithelial-to-mesenchymal transition (EMT), and parental exposure to toxicants. Our group previously reported that a history of paternal toxicant exposure increased the risk of prematurity and low birth weight in offspring. A history of paternal toxicant exposure also increased the offspring’s risk of new BPD and disease severity was increased in offspring who additionally received a supplemental formula diet, which has also been linked to poor lung development. Risk factors associated with new BPD are well-defined, but it is unclear whether the disease can be prevented. Herein, we assessed whether a paternal fish oil diet could attenuate the development of new BPD in the offspring of toxicant exposed mice, with and without neonatal formula feeding. We investigated the impact of a paternal fish oil diet preconception because we previously reported that this intervention reduces the risk of TCDD associated placental dysfunction, prematurity, and low birth weight. We found that a paternal fish oil diet significantly reduced the risk of new BPD in neonatal mice with a history of paternal toxicant exposure regardless of neonatal diet. Furthermore, our evidence suggests that the protective effects of a paternal fish oil diet are mediated in part by the modulation of small molecules involved in EMT. View Full-Text
Keywords: multigenerational; toxicants; bronchopulmonary dysplasia; therapeutics; lung development multigenerational; toxicants; bronchopulmonary dysplasia; therapeutics; lung development
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MDPI and ACS Style

Rumph, J.T.; Rayford, K.J.; Stephens, V.R.; Ameli, S.; Nde, P.N.; Osteen, K.G.; Bruner-Tran, K.L. A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice. Toxics 2022, 10, 7. https://doi.org/10.3390/toxics10010007

AMA Style

Rumph JT, Rayford KJ, Stephens VR, Ameli S, Nde PN, Osteen KG, Bruner-Tran KL. A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice. Toxics. 2022; 10(1):7. https://doi.org/10.3390/toxics10010007

Chicago/Turabian Style

Rumph, Jelonia T., Kayla J. Rayford, Victoria R. Stephens, Sharareh Ameli, Pius N. Nde, Kevin G. Osteen, and Kaylon L. Bruner-Tran. 2022. "A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice" Toxics 10, no. 1: 7. https://doi.org/10.3390/toxics10010007

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