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Open AccessCommunication

Acute Oral Toxicity and Genotoxicity of Polysaccharide Fraction from Young Barley Leaves (Hordeum vulgare L.)

Research Group of Traditional Food, Korea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, Korea
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
Korean Convergence Medicine Major KIOM, University of Science & Technology (UST), Daejeon 34054, Korea
Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 02447, Korea
Author to whom correspondence should be addressed.
Current affiliation: Technology Evaluation Team, Foundation of Agricultural Technology Commercialization and Transfer, Iksan 54667, Korea.
Foods 2020, 9(6), 809;
Received: 20 May 2020 / Revised: 9 June 2020 / Accepted: 16 June 2020 / Published: 19 June 2020
(This article belongs to the Special Issue Development of Functional Food Ingredients from Natural Resources)
Polysaccharides isolated from various plants are considered precious bioactive materials owing to their potent biological activities. Previously, we prepared a polysaccharide fraction (BLE0) isolated from young barley leaves (Hordeum vulgare L.), demonstrating its anti-osteoporotic and immunostimulatory activities. However, data regarding BLE0 toxicity is lacking. To establish its safety, in vitro genotoxicity (chromosomal aberration and bacterial reverse mutation assays) and acute oral toxicity assays were conducted. In the in vitro genotoxicity assays, bacterial reverse mutation and chromosomal aberration assays showed that BLE0 possessed no mutagenicity or clastogenicity. Furthermore, the median lethal dose (LD50) of BLE0 was higher than 5000 mg/kg in female and male Sprague-Dawley (SD) rats and no adverse effects were observed in terms of mortality and abnormal changes in clinical signs (body weight and necropsy). Based on these results, BLE0 was found to be safe with regards to genotoxicity under our test conditions, demonstrating no acute oral toxicity up to 5000 mg/kg in SD rats. View Full-Text
Keywords: Hordeum vulgare L.; polysaccharides; toxicity Hordeum vulgare L.; polysaccharides; toxicity
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Cho, C.-W.; Song, Y.-R.; Lim, W.-C.; Hwang, Y.-H.; Rhee, Y.K.; Choi, J.W.; Lee, K.-T.; Hong, H.-D. Acute Oral Toxicity and Genotoxicity of Polysaccharide Fraction from Young Barley Leaves (Hordeum vulgare L.). Foods 2020, 9, 809.

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