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Article

Hepatoprotective Effects of Steamed and Freeze-Dried Mature Silkworm Larval Powder against Ethanol-Induced Fatty Liver Disease in Rats

1
College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam 13488, Korea
2
Department of Agricultural Biology, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, Korea
*
Author to whom correspondence should be addressed.
Foods 2020, 9(3), 285; https://doi.org/10.3390/foods9030285
Received: 12 February 2020 / Revised: 27 February 2020 / Accepted: 29 February 2020 / Published: 4 March 2020
Silkworm, Bombyx mori, contains high amounts of beneficial nutrients, including amino acids, proteins, essential minerals, and omega-3 fatty acids. We have previously reported a technique for producing steamed and freeze-dried mature silkworm larval powder (SMSP), which makes it easier to digest mature silkworm. In this study, we investigated the preventive effects of SMSP on alcoholic fatty liver disease and elucidated its mechanism of action. Male Sprague-Dawley rats treated with SMSP (50 mg/kg) or normal diet (AIN-76A) were administered 25% ethanol (3 g/kg body weight) by oral gavage for 4 weeks. SMSP administration for 4 weeks significantly decreased hepatic fat accumulation in ethanol-treated rats by modulating lipogenesis and fatty acid oxidation-related molecules such as sirtuin 1, AMP-activated protein kinase, and acetyl-CoA carboxylase 1. Moreover, SMSP administration significantly diminished the levels of triglyceride in liver tissues by as much as 35%, as well as lowering the serum levels of triglyceride, gamma glutamyl transpeptidase, alanine transaminase, and aspartate aminotransferase in ethanol-treated rats. SMSP supplementation also decreased the pro-inflammatory tumor necrosis factor-alpha and interleukin 1 beta levels and cytochrome P450 2E1 generating oxidative stress. These results suggest that SMSP administration may be possible for the prevention of alcoholic liver disease. View Full-Text
Keywords: steamed and freeze-dried mature silkworm larval powder; alcoholic fatty liver; ethanol; lipogenesis; fatty acid oxidation; Sprague-Dawley rats steamed and freeze-dried mature silkworm larval powder; alcoholic fatty liver; ethanol; lipogenesis; fatty acid oxidation; Sprague-Dawley rats
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MDPI and ACS Style

Lee, D.-Y.; Hong, K.-S.; Song, M.-Y.; Yun, S.-M.; Ji, S.-D.; Son, J.-G.; Kim, E.-H. Hepatoprotective Effects of Steamed and Freeze-Dried Mature Silkworm Larval Powder against Ethanol-Induced Fatty Liver Disease in Rats. Foods 2020, 9, 285. https://doi.org/10.3390/foods9030285

AMA Style

Lee D-Y, Hong K-S, Song M-Y, Yun S-M, Ji S-D, Son J-G, Kim E-H. Hepatoprotective Effects of Steamed and Freeze-Dried Mature Silkworm Larval Powder against Ethanol-Induced Fatty Liver Disease in Rats. Foods. 2020; 9(3):285. https://doi.org/10.3390/foods9030285

Chicago/Turabian Style

Lee, Da-Young, Kyung-Sook Hong, Moon-Young Song, Sun-Mi Yun, Sang-Deok Ji, Jong-Gon Son, and Eun-Hee Kim. 2020. "Hepatoprotective Effects of Steamed and Freeze-Dried Mature Silkworm Larval Powder against Ethanol-Induced Fatty Liver Disease in Rats" Foods 9, no. 3: 285. https://doi.org/10.3390/foods9030285

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