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Article

Anxiolytic, Antidepression, and Memory-Enhancing Effects of the Novel Instant Soup RJ6601 in the Middle-Aged of Female Rats

by
Rujikan Chaisanam
1,
Jintanaporn Wattanathorn
2,3,*,
Wipawee Thukham-mee
2,3,
Nawanant Piyavhatkul
4 and
Pongsatorn Paholpak
4
1
Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
2
Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
3
Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40002, Thailand
4
Department Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
*
Author to whom correspondence should be addressed.
Foods 2024, 13(14), 2170; https://doi.org/10.3390/foods13142170
Submission received: 8 June 2024 / Revised: 1 July 2024 / Accepted: 2 July 2024 / Published: 9 July 2024
(This article belongs to the Special Issue Functional Food Used for Regulating Inflammation and Metabolism in Chronic Diseases)
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Abstract

Due to the health benefits of polyphenols and dietary fiber in combating mental disorders, we hypothesized that a polyphenol- and dietary fiber-enriched soup (RJ6601) would improve mental wellness in a rat model of middle-aged women. To test this hypothesis, female Wistar rats aged 18 months (350–450 g) were orally administered RJ6601 at doses of 200 and 400 mg/kg BW for 28 days. The anxiolytic, antidepression, and memory-enhancing effects were assessed every 7 days throughout the study period. The neuron density and levels of activities of AChE, total MAO, MAO-A, MAO-B, MDA, SOD, CAT, GSH-Px, IL-1β, IL-6, and BDNF in the prefrontal cortex at the end of study were also investigated. Furthermore, the amounts of Lactobacillus spp. and Bifidobacterium spp. in their feces were also determined. The results revealed that the developed soup shows anxiolytic, antidepression, and memory-enhancing effects. An increased neuron density; reductions in AChE, total MAO, MAO-A, MAO-B, and MDA; and an elevation of serum BDNF, together with increased amounts of both bacterial species in feces, were also observed. Our results suggest that RJ6601 is a potential mental wellness promotion supplement that enhances BDNF levels, brain plasticity, neurotransmitter balance, and oxidative stress and inflammation status, along with improving microbiota.
Keywords: polyphenol; dietary fiber; mental health; anxiolytic; antidepression; memory-enhancing effect polyphenol; dietary fiber; mental health; anxiolytic; antidepression; memory-enhancing effect
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MDPI and ACS Style

Chaisanam, R.; Wattanathorn, J.; Thukham-mee, W.; Piyavhatkul, N.; Paholpak, P. Anxiolytic, Antidepression, and Memory-Enhancing Effects of the Novel Instant Soup RJ6601 in the Middle-Aged of Female Rats. Foods 2024, 13, 2170. https://doi.org/10.3390/foods13142170

AMA Style

Chaisanam R, Wattanathorn J, Thukham-mee W, Piyavhatkul N, Paholpak P. Anxiolytic, Antidepression, and Memory-Enhancing Effects of the Novel Instant Soup RJ6601 in the Middle-Aged of Female Rats. Foods. 2024; 13(14):2170. https://doi.org/10.3390/foods13142170

Chicago/Turabian Style

Chaisanam, Rujikan, Jintanaporn Wattanathorn, Wipawee Thukham-mee, Nawanant Piyavhatkul, and Pongsatorn Paholpak. 2024. "Anxiolytic, Antidepression, and Memory-Enhancing Effects of the Novel Instant Soup RJ6601 in the Middle-Aged of Female Rats" Foods 13, no. 14: 2170. https://doi.org/10.3390/foods13142170

APA Style

Chaisanam, R., Wattanathorn, J., Thukham-mee, W., Piyavhatkul, N., & Paholpak, P. (2024). Anxiolytic, Antidepression, and Memory-Enhancing Effects of the Novel Instant Soup RJ6601 in the Middle-Aged of Female Rats. Foods, 13(14), 2170. https://doi.org/10.3390/foods13142170

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