Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet

Fang, Jiangmin; Zeng, Lirong; He, Yalun; Liu, Xiong; Zhang, Tongcun; Wang, Qiong

doi:10.3390/foods11213325

Open AccessArticle

Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet

by

Jiangmin Fang

^†,

Lirong Zeng

^†,

Yalun He

,

Xiong Liu

,

Tongcun Zhang

and

Qiong Wang

^*

College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, China

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Foods 2022, 11(21), 3325; https://doi.org/10.3390/foods11213325

Submission received: 16 September 2022 / Revised: 14 October 2022 / Accepted: 20 October 2022 / Published: 23 October 2022

(This article belongs to the Special Issue Bioactive and (Poly)Phenolic Compounds: Characterization & Properties into Food and Health Benefits)

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Abstract

Dietary tannic acid, as a natural polyphenolic, has many important biological activities. This study aimed to investigate the effect of dietary tannic acid on obesity and gut microbiota in mice with a high-fat diet. Male C57BL/6J mice fed a high-fat diet were treated with dietary tannic acid for eight weeks. Results showed that dietary tannic acid reduced the body weight gain, regulated glycolipid metabolism, improved the insulin resistance, and attenuated the liver oxidative stress in high-fat diet-fed mice. Moreover, both dietary tannic acid intervention groups repaired the gut barrier damage caused by a high-fat diet, especially in the 50 mg/kg/d dietary tannic acid intervention group. Interestingly, the effect of dietary tannic acid on serum endotoxin lipopolysaccharide (LPS) content was correlated with the abundance of the LPS-producing microbiota. In addition, dietary tannic acid altered the abundance of obesity-related gut microbiota (Firmicutes, Bacteroidetes, Bacteroides, Alistipes, and Odoribacter) in the 150 mg/kg/d dietary tannic acid intervention group, while it was not effective in the 50 mg/kg/d dietary tannic acid intervention group. These findings suggested the potential effect of dietary tannic acid for the prevention and control of obesity.

Keywords: obesity; dietary tannic acid; oxidative stress; glycolipid metabolism; gut barrier; gut microbiota

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MDPI and ACS Style

Fang, J.; Zeng, L.; He, Y.; Liu, X.; Zhang, T.; Wang, Q. Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet. Foods 2022, 11, 3325. https://doi.org/10.3390/foods11213325

AMA Style

Fang J, Zeng L, He Y, Liu X, Zhang T, Wang Q. Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet. Foods. 2022; 11(21):3325. https://doi.org/10.3390/foods11213325

Chicago/Turabian Style

Fang, Jiangmin, Lirong Zeng, Yalun He, Xiong Liu, Tongcun Zhang, and Qiong Wang. 2022. "Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet" Foods 11, no. 21: 3325. https://doi.org/10.3390/foods11213325

APA Style

Fang, J., Zeng, L., He, Y., Liu, X., Zhang, T., & Wang, Q. (2022). Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet. Foods, 11(21), 3325. https://doi.org/10.3390/foods11213325

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Effects of Dietary Tannic Acid on Obesity and Gut Microbiota in C57BL/6J Mice Fed with High-Fat Diet

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