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Article

Saccharomyces cerevisiae I4 Showed Alleviating Effects on Dextran Sulfate Sodium-Induced Colitis of Balb/c Mice

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School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China
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Dalian Probiotics Function Research Key Laboratory, Dalian Polytechnic University, Dalian 116034, China
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Xinjiang Tianrun Biological Technology Co., Ltd., Urumchi 830011, China
*
Author to whom correspondence should be addressed.
Academic Editor: Albert Bordons
Foods 2022, 11(10), 1436; https://doi.org/10.3390/foods11101436
Received: 12 March 2022 / Revised: 6 May 2022 / Accepted: 10 May 2022 / Published: 16 May 2022
(This article belongs to the Topic Probiotics, Prebiotics and Postbiotics in Human Health)
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The purpose of this study was to investigate the ameliorating effects of three yeast strains, Saccharomyces cerevisiae I4, Clavispora lusitaniae 30 and Pichia kudriavzevii 11, isolated from traditional fermented dairy food in Xinjiang, China, on the ulcerative colitis symptoms of Balb/c mice treated by dextran sulfate sodium (DSS). Among which, S. cerevisiae I4 had good tolerance to simulated gastrointestinal juice and strong adhesion to HT–29 cells monolayers. Furthermore, the three yeast strains were oral administered to Balb/c mice with DSS induced colitis. The weight loss, colon shortening and histological injury of colitis mice were ameliorated. Then, oral administration of S. cerevisiae I4 improved the immune state by reducing the contents of TNF–α, IL–6 and IL–1β and increasing immunoglobulin. The relative expression of intestinal barrier proteins Claudin–1, Occludin and Zonula Occludins–1 (ZO–1) of the mice enhanced, and the short chain fatty acids (SCFAs) content such as Propionic acid, Butyric acid, Isobutyric acid and Isovaleric acid in the feces of the mice increased to varying degrees, after S. cerevisiae I4 treatment compared with the model group of drinking 3% DSS water without yeast treatment. Moreover, S. cerevisiae I4 treatment lifted the proportion of beneficial bacteria such as Muribaculaceae, Lactobacillaceae and Rikenellaceae in the intestinal tract of the mice, the abundance of harmful bacteria such as Staphylococcus aureus and Turicibacter was decreased. These results suggested that S. cerevisiae I4 could alleviate DSS induced colitis in mice by enhancing intestinal barrier function and regulating intestinal flora balance. View Full-Text
Keywords: Saccharomyces cerevisiae I4; probiotic; intestinal flora; intestinal barrier; SCFAS Saccharomyces cerevisiae I4; probiotic; intestinal flora; intestinal barrier; SCFAS
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MDPI and ACS Style

Meng, Y.; Zhang, L.; Li, P.; Yu, J.; Mu, G.; Li, X.; Tuo, Y. Saccharomyces cerevisiae I4 Showed Alleviating Effects on Dextran Sulfate Sodium-Induced Colitis of Balb/c Mice. Foods 2022, 11, 1436. https://doi.org/10.3390/foods11101436

AMA Style

Meng Y, Zhang L, Li P, Yu J, Mu G, Li X, Tuo Y. Saccharomyces cerevisiae I4 Showed Alleviating Effects on Dextran Sulfate Sodium-Induced Colitis of Balb/c Mice. Foods. 2022; 11(10):1436. https://doi.org/10.3390/foods11101436

Chicago/Turabian Style

Meng, Yuan, Lijuan Zhang, Panpan Li, Jiang Yu, Guangqing Mu, Xinling Li, and Yanfeng Tuo. 2022. "Saccharomyces cerevisiae I4 Showed Alleviating Effects on Dextran Sulfate Sodium-Induced Colitis of Balb/c Mice" Foods 11, no. 10: 1436. https://doi.org/10.3390/foods11101436

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