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Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study

Department of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, Via S. Allende, 84081 Baronissi, Italy
Department of Economics and Statistics, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy
Department of Radiology, School of Medicine, University of Molise, Via Giovanni Paolo II, Contrada “Tappino”, 86100 Campobasso, Italy
Author to whom correspondence should be addressed.
Dent. J. 2021, 9(1), 1;
Received: 17 November 2020 / Revised: 14 December 2020 / Accepted: 17 December 2020 / Published: 22 December 2020
(This article belongs to the Section Oral Hygiene, Periodontology and Peri-implant Diseases)
Oral pathogens have been identified in bioptic specimens from Age-Related Macular Degeneration (ARMD) patients, and alveolar bone loss has been related to ARMD. Therefore, the possible association between ARMD and periodontal disease was investigated in the present case-control study, evaluating clinical and radiographic periodontal parameters, primarily, in cases vs. controls and, secondarily, in relation to ARMD risk factors, in cases, to highlight a possible pathogenic link between the disorders. Forty ARMD cases and 40 non-ARMD controls, matched for age (±3 years) and gender and homogeneous for ARMD risk factors, therefore comparable, underwent full-mouth periodontal charting, panoramic radiograph, and medical data, including ARMD risk factors, collection. Statistical analysis was conducted using the language R. Comparisons between groups were made using both traditional t-tests and Yuen’s test with bootstrap calibration. Enrolled subjects were ≥55 years old, and 50 females and 30 males were equally distributed among the two groups. No statistically significant difference was found in clinical and radiographic periodontal parameters in cases vs. controls. In the case group, no differences were found when relating the periodontal parameters to ARMD risk factors, except for Clinical Attachment Level values that were statistically significantly higher in hypertensive ARMD subjects. A possible association between periodontal disease and ARMD may be hypothesized in hypertensive ARMD subjects, with hypertension as a possible pathogenic link between the disorders. View Full-Text
Keywords: ARMD; macular degeneration; periodontitis ARMD; macular degeneration; periodontitis
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MDPI and ACS Style

Di Spirito, F.; La Rocca, M.; De Bernardo, M.; Rosa, N.; Sbordone, C.; Sbordone, L. Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study. Dent. J. 2021, 9, 1.

AMA Style

Di Spirito F, La Rocca M, De Bernardo M, Rosa N, Sbordone C, Sbordone L. Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study. Dentistry Journal. 2021; 9(1):1.

Chicago/Turabian Style

Di Spirito, Federica, Michele La Rocca, Maddalena De Bernardo, Nicola Rosa, Carolina Sbordone, and Ludovico Sbordone. 2021. "Possible Association of Periodontal Disease and Macular Degeneration: A Case-Control Study" Dentistry Journal 9, no. 1: 1.

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