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Article

Association between Vitamin D and Candida-Associated Denture Stomatitis

1
Department of Oral Medicine and Periodontology, Faculty of Dental Medicine, University of Rijeka, Kresimirova 40, 51 000 Rijeka, Croatia
2
Dental Clinic, Clinical Hospital Center Rijeka, Kresimirova 40, 51 000 Rijeka, Croatia
3
Department of Restorative Dentistry and Endodontics, Faculty of Dental Medicine, University of Rijeka, Kresimirova 40, 51 000 Rijeka, Croatia
4
Department of Prosthodontics, Faculty of Dental Medicine, University of Rijeka, Kresimirova 40, 51 000 Rijeka, Croatia
*
Author to whom correspondence should be addressed.
Dent. J. 2020, 8(4), 121; https://doi.org/10.3390/dj8040121
Received: 21 July 2020 / Revised: 25 September 2020 / Accepted: 14 October 2020 / Published: 21 October 2020
(This article belongs to the Special Issue Oral Medicine)
Candida-associated denture stomatitis (CADS) is a fungal infection affecting 60–65% of denture wearers. Its etiology is complex and multifactorial and often associated with host immunodeficiency. Evidence exists that vitamin D has potential immunomodulatory and anti-inflammatory effects. The aim of this case–control study was to assess the association between vitamin D levels and CADS. The study included 32 complete denture wearers with CADS and 32 sex- and age-matched complete denture wearers without CADS. The patients were clinically examined, and the severity of denture stomatitis was assessed according to Newton’s classification scale. The serum vitamin D level was determined via the use of an electrochemiluminescence assay. The vitamin D level in the CADS group and control group was 54.68 ± 17.07 and 56.82 ± 17.75 nmol/L, respectively. There was no significant difference between the groups (p = 0.622). Univariate logistic regression analysis showed that the presence of CADS was not associated with hypovitaminosis D (odds ratio (OR) = 1.44; 95% confidence interval (CI) = 0.37–5.54). It can be concluded that vitamin D is not associated with CADS and does not play a significant role in host susceptibility to CADS. This finding suggests that vitamin D screening is not indicated routinely in patients with Candida-associated denture stomatitis. View Full-Text
Keywords: 25-hydroxyvitamin D; candidiasis; oral; stomatitis; denture; vitamin D 25-hydroxyvitamin D; candidiasis; oral; stomatitis; denture; vitamin D
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MDPI and ACS Style

Muhvić-Urek, M.; Saltović, E.; Braut, A.; Kovačević Pavičić, D. Association between Vitamin D and Candida-Associated Denture Stomatitis. Dent. J. 2020, 8, 121. https://doi.org/10.3390/dj8040121

AMA Style

Muhvić-Urek M, Saltović E, Braut A, Kovačević Pavičić D. Association between Vitamin D and Candida-Associated Denture Stomatitis. Dentistry Journal. 2020; 8(4):121. https://doi.org/10.3390/dj8040121

Chicago/Turabian Style

Muhvić-Urek, Miranda, Ema Saltović, Alen Braut, and Daniela Kovačević Pavičić. 2020. "Association between Vitamin D and Candida-Associated Denture Stomatitis" Dentistry Journal 8, no. 4: 121. https://doi.org/10.3390/dj8040121

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