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Article

Effectiveness of a Novel Dentifrice Containing Stabilized Chlorine Dioxide, Sarkosyl, and Sodium Fluoride

1
Department of Periodontology, Stony Brook University, Stony Brook, NY 11794, USA
2
Cooley Consulting, Inc., Wyoming, OH 45215, USA
3
Rowpar Pharmaceuticals, Inc., Scottsdale, AZ 85260, USA
*
Author to whom correspondence should be addressed.
Dent. J. 2020, 8(4), 122; https://doi.org/10.3390/dj8040122
Received: 9 July 2020 / Revised: 20 October 2020 / Accepted: 21 October 2020 / Published: 27 October 2020
(This article belongs to the Section Oral Hygiene, Periodontology and Peri-implant Diseases)
This in vitro study evaluated the effectiveness of a novel dentifrice containing stabilized chlorine dioxide, sodium lauroyl sarcosinate (sarkosyl), and sodium fluoride in enhancing enamel fluoride uptake, remineralization, pellicle cleaning and inhibiting biofilm regrowth. Remineralization was measured by fluoride uptake and surface microhardness assessment tests. Artificial stains were removed and scored based on pellicle cleaning ratio. Biofilm regrowth was measured by counting colonies on the agar plates. All studies were conducted using bovine teeth specimens. The efficacy of Toothpaste C (CloSYS anticavity toothpaste) was compared with United States Pharmacopoeia Reference Dentifrice, Toothpaste B (discontinued CloSYS anticavity toothpaste formulation) and leading commercial toothpastes. The enamel fluoride uptake and remineralization by Toothpaste C was 96.1% to 303.3% and 38.0% to 102.4% higher than the tested toothpastes, respectively. The mean pellicle cleaning ratio of Toothpaste C was similar to American Dental Association Reference Material. Toothpaste C had a significant reduction in regrowth of the oral polymicrobial biofilm compared to the control. All tested toothpastes contained 0.24% sodium fluoride. Toothpaste C exhibited significantly superior performance towards fluoride uptake and remineralization compared to the tested toothpastes. Therefore, toothpaste ingredients other than sodium fluoride accounted for the enhanced fluoride uptake and remineralization. View Full-Text
Keywords: stabilized chlorine dioxide; sarkosyl; sodium fluoride; enamel remineralization; anticavity; anticaries; remineralization; biofilm; fluoride uptake; polymicrobial biofilm stabilized chlorine dioxide; sarkosyl; sodium fluoride; enamel remineralization; anticavity; anticaries; remineralization; biofilm; fluoride uptake; polymicrobial biofilm
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MDPI and ACS Style

Mynenivenkatasatya, S.R.; Wang, H.; Cooley, W.; Garcia-Smith, E.; Shewale, J.; Ratcliff, J. Effectiveness of a Novel Dentifrice Containing Stabilized Chlorine Dioxide, Sarkosyl, and Sodium Fluoride. Dent. J. 2020, 8, 122. https://doi.org/10.3390/dj8040122

AMA Style

Mynenivenkatasatya SR, Wang H, Cooley W, Garcia-Smith E, Shewale J, Ratcliff J. Effectiveness of a Novel Dentifrice Containing Stabilized Chlorine Dioxide, Sarkosyl, and Sodium Fluoride. Dentistry Journal. 2020; 8(4):122. https://doi.org/10.3390/dj8040122

Chicago/Turabian Style

Mynenivenkatasatya, Srinivas R., Howard Wang, William Cooley, Esmeralda Garcia-Smith, Jaiprakash Shewale, and James Ratcliff. 2020. "Effectiveness of a Novel Dentifrice Containing Stabilized Chlorine Dioxide, Sarkosyl, and Sodium Fluoride" Dentistry Journal 8, no. 4: 122. https://doi.org/10.3390/dj8040122

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