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Article

Treatment of Peri-Implant Mucositis with Repeated Application of Chlorhexidine Chips or Gel during Supportive Therapy—A Randomized Clinical Trial

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Clinic for Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, CH 8032 Zurich, Switzerland
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Alte Gasse 24, 6438 Ibach SZ, Switzerland
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Center of Dental Medicine, University of Zurich, CH 8032 Zurich, Switzerland
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Author to whom correspondence should be addressed.
Dent. J. 2019, 7(4), 115; https://doi.org/10.3390/dj7040115
Received: 15 October 2019 / Revised: 17 November 2019 / Accepted: 3 December 2019 / Published: 11 December 2019
(This article belongs to the Section Oral Hygiene, Periodontology and Peri-implant Diseases)
Background: To assess the effect of chlorhexidine (CHX) chip application in patients with peri-implant mucositis as compared to CHX gel application. Methods: In peri-implant sites with mucositis, CHX gel was applied in the control group (GC) and CHX chips in the test group (CC) at baseline and after three months. At baseline and after six months, peri-implant pocket depths (PPD), bleeding-on-probing (BOP) and activated matrix metalloproteinase-8 (aMMP8) were assessed. Longitudinal changes were tested for inter-group differences. Results: Thirty-two patients were treated. BOP was more reduced (p = 0.006) in CC than in GC, with means and standard deviations of 46 ± 28% and 17 ± 27%, respectively. PPD was more reduced (p = 0.002) in CC than in GC with 0.65 ± 0.40 mm and 0.18 ± 0.32 mm, respectively. Regarding BOP, the percentages of improved, unchanged and worsened sites accounted for 32%, 61% and 7% in GC and 46%, 53% and 1% in CC, respectively. For probing pocket depth, the according values were 26%, 66% and 8% (GC) versus 57%, 38% and 5% (CC). Conclusions: During supportive therapy, repeated CHX chip application might resolve marginal peri-implant inflammation in terms of bleeding better than CHX gel. View Full-Text
Keywords: peri-implantitis; chlorhexidine; local anti-infective agents; maintenance peri-implantitis; chlorhexidine; local anti-infective agents; maintenance
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MDPI and ACS Style

Sahrmann, P.; Bettschart, C.; Wiedemeier, D.B.; Al-Majid, A.; Attin, T.; Schmidlin, P.R. Treatment of Peri-Implant Mucositis with Repeated Application of Chlorhexidine Chips or Gel during Supportive Therapy—A Randomized Clinical Trial. Dent. J. 2019, 7, 115. https://doi.org/10.3390/dj7040115

AMA Style

Sahrmann P, Bettschart C, Wiedemeier DB, Al-Majid A, Attin T, Schmidlin PR. Treatment of Peri-Implant Mucositis with Repeated Application of Chlorhexidine Chips or Gel during Supportive Therapy—A Randomized Clinical Trial. Dentistry Journal. 2019; 7(4):115. https://doi.org/10.3390/dj7040115

Chicago/Turabian Style

Sahrmann, Philipp, Cyrill Bettschart, Daniel B. Wiedemeier, Ahmed Al-Majid, Thomas Attin, and Patrick R. Schmidlin 2019. "Treatment of Peri-Implant Mucositis with Repeated Application of Chlorhexidine Chips or Gel during Supportive Therapy—A Randomized Clinical Trial" Dentistry Journal 7, no. 4: 115. https://doi.org/10.3390/dj7040115

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