Next Article in Journal
Evaluation of a Digital Protocol for Pre-Surgical Orthopedic Treatment of Cleft Lip and Palate in Newborn Patients: A Pilot Study
Previous Article in Journal
Platelet Adhesion on Commercially Pure Titanium Plates in Vitro II. Immunofluorescence Visualization of PDGF-B, TGFβ1, and PPARγ Released from Activated Adherent Platelets
Article

Biomodification of a Class-V Restorative Material by Incorporation of Bioactive Agents

1
School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK
2
School of Dentistry, Taibah University, Medina 42353, Saudi Arabia
3
College of Dentistry, University of Mosul, Mosul 41002, Iraq
4
School of Dentistry, Marquette University, Milwaukee, WI 53233, USA
*
Author to whom correspondence should be addressed.
Dent. J. 2019, 7(4), 110; https://doi.org/10.3390/dj7040110
Received: 1 November 2019 / Revised: 25 November 2019 / Accepted: 27 November 2019 / Published: 29 November 2019
(This article belongs to the Section Dental Materials)
Restoring subgingival class-V cavities successfully, demand special biological properties from a restorative material. This study aimed to assess the effects of incorporating bioactive materials to glass ionomer cement (GIC) on its mechanical and biological properties. Hydroxyapatite, chitosan, chondroitin sulphate, bioglass, gelatine and processed bovine dentin were incorporated into a GIC restorative material. Compressive strength, biaxial flexural strength (BFS), hardness, setting and working time measurements were investigated. Biocompatibility of the new materials was assessed using both monolayer cell cultures of normal oral fibroblasts (NOF) and TR146 keratinocytes, and a 3D-tissue engineered human oral mucosa model (3D-OMM) using presto-blue tissue viability assay and histological examination. Significant reduction in the compressive strength and BFS of gelatine-modified discs was observed, while chondroitin sulphate-modified discs had reduced BFS only (p value > 0.05). For hardness, working and setting times, only bioglass caused significant increase in the working time. NOF viability was significantly increased when exposed to GIC-modified with bovine dentine, bioglass and chitosan. Histological examination showed curling and growth of the epithelial layer toward the disc space, except for the GIC modified with gelatine. This study has highlighted the potential for clinical application of the modified GICs with hydroxyapatite, chitosan, bioglass and bovine dentine in subgingival class-V restorations. View Full-Text
Keywords: dental materials; glass ionomer cement; biocompatibility; oral mucosa; biomodification dental materials; glass ionomer cement; biocompatibility; oral mucosa; biomodification
Show Figures

Figure 1

MDPI and ACS Style

Binaljadm, T.; Moorehead, R.; Almela, T.; Franklin, K.; Tayebi, L.; Moharamzadeh, K. Biomodification of a Class-V Restorative Material by Incorporation of Bioactive Agents. Dent. J. 2019, 7, 110. https://doi.org/10.3390/dj7040110

AMA Style

Binaljadm T, Moorehead R, Almela T, Franklin K, Tayebi L, Moharamzadeh K. Biomodification of a Class-V Restorative Material by Incorporation of Bioactive Agents. Dentistry Journal. 2019; 7(4):110. https://doi.org/10.3390/dj7040110

Chicago/Turabian Style

Binaljadm, Tahani, Robert Moorehead, Thafar Almela, Kirsty Franklin, Lobat Tayebi, and Keyvan Moharamzadeh. 2019. "Biomodification of a Class-V Restorative Material by Incorporation of Bioactive Agents" Dentistry Journal 7, no. 4: 110. https://doi.org/10.3390/dj7040110

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop