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Open AccessArticle

Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs

Unigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA
Univera, Inc. 78, Achasan-ro, Seongdong-gu, Seoul 04789, Korea
Naturetech, Inc. 29-8, Yongjeong-gil, Chopyeong-myeon, Jincheon-gun, Chungcheongbuk-do 27858, Korea
Korea Institute of Oriental Medicine. 1672, Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
Department of Veterinary Clinics, College of Veterinary Medicine, Seoul National University. 1, Gwanak-ro, Gwanak-gu, Seoul 08826, Korea
Author to whom correspondence should be addressed.
Dent. J. 2019, 7(2), 33;
Received: 29 January 2019 / Revised: 19 March 2019 / Accepted: 22 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Pathogenesis of Periodontal Disease)
Periodontal disease is an inflammatory disease of the gum caused by a formation of a plaque that triggers immune responses and inflammation leading to the destruction of tissues surrounding and supporting the teeth. Chronic usage of synthetic chemicals and antibiotics is limited by undesired adverse events to the host. A botanical composition (UP446), which consists primarily of bioflavonoids such as baicalin from roots of Scutellaria baicalensis and catechins from heartwoods of Acacia catechu, was evaluated for its effect on ligature-induced periodontal disease in beagle dogs. Disease model was induced in 20 male and female dogs. After a 12-week induction of periodontitis, animals were assigned to a placebo, positive control (doxycycline), and two treatment groups consisting of five animals each. The placebo group was only administrated to normal dog chow (25 g/kg/day). In the doxycycline treatment group, animals were fed a normal diet (25 g/kg/day) and doxycycline (5 mg/kg) was orally administrated every day. Treatment of UP446 was done by feeding the regular diet formulated with 0.1% and 0.2% of UP446 by weight. Clinical indices such as plaque index (PI), gingival index (GI), clinical attachment level (CAL), probing pocket depth (PPD), and bleeding on probing (BoP) were measured every two weeks for 12 weeks. UP446 administered to beagle dogs for 12 weeks at 0.1% and 0.2% resulted in statistically significant reductions in gingivitis, pocket depth, loss of attachment, and gum bleeding. UP446 could potentially be used alone or as an adjunct with other oral hygiene preparations for periodontal disease in both human and companion animals. View Full-Text
Keywords: periodontitis; periodontal disease; beagle dogs; Scutellaria baicalensis; Acacia catechu; UP446 periodontitis; periodontal disease; beagle dogs; Scutellaria baicalensis; Acacia catechu; UP446
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Yimam, M.; Brownell, L.; Do, S.-G.; Lee, Y.-C.; Kim, D.S.; Seo, K.; Jeong, M.; Kim, S.; Jia, Q. Protective Effect of UP446 on Ligature-Induced Periodontitis in Beagle Dogs. Dent. J. 2019, 7, 33.

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