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Article

Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach

1
Biomaterials Science Center, University of Basel, Gewerbestrasse 14, 4123 Allschwil, Switzerland
2
University of Applied Sciences and Arts Northwestern Switzerland FHNW, Gründenstrasse 40, 4132 Muttenz, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Tolga F. Tozum
Dent. J. 2015, 3(4), 111-122; https://doi.org/10.3390/dj3040111
Received: 31 July 2015 / Accepted: 5 October 2015 / Published: 10 October 2015
(This article belongs to the Special Issue Tomography in Dentistry)
Micro computed tomography has been combined with dedicated data analysis for the in vitro quantification of sub-surface enamel lesion mineralization. Two artificial white spot lesions, generated on a human molar crown in vitro, were examined. One lesion was treated with a self-assembling peptide intended to trigger nucleation of hydroxyapatite crystals. We non-destructively determined the local X-ray attenuation within the specimens before and after treatment. The three-dimensional data was rigidly registered. Three interpolation methods, i.e., nearest neighbor, tri-linear, and tri-cubic interpolation were evaluated. The mineralization of the affected regions was quantified via joint histogram analysis, i.e., a voxel-by-voxel comparison of the tomography data before and after mineralization. After ten days incubation, the mean mineralization coefficient reached 35.5% for the peptide-treated specimen compared to 11.5% for the control. This pilot study does not give any evidence for the efficacy of peptide treatment nor allows estimating the necessary number of specimens to achieve significance, but shows a sound methodological approach on the basis of the joint histogram analysis. View Full-Text
Keywords: enamel caries; mineralization; demineralization; self-assembling peptide; image registration; micro computed tomography; joint histogram enamel caries; mineralization; demineralization; self-assembling peptide; image registration; micro computed tomography; joint histogram
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MDPI and ACS Style

Deyhle, H.; Dziadowiec, I.; Kind, L.; Thalmann, P.; Schulz, G.; Müller, B. Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach. Dent. J. 2015, 3, 111-122. https://doi.org/10.3390/dj3040111

AMA Style

Deyhle H, Dziadowiec I, Kind L, Thalmann P, Schulz G, Müller B. Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach. Dentistry Journal. 2015; 3(4):111-122. https://doi.org/10.3390/dj3040111

Chicago/Turabian Style

Deyhle, Hans, Iwona Dziadowiec, Lucy Kind, Peter Thalmann, Georg Schulz, and Bert Müller. 2015. "Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach" Dentistry Journal 3, no. 4: 111-122. https://doi.org/10.3390/dj3040111

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