An Umbrella Review of Meta-Analyses on Transcrestal Sinus Floor Elevation: Methodological Quality, Primary-Study Overlap, and Interpretive Boundaries
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Design and Reporting Standards
2.2. Eligibility Criteria
2.3. Information Sources and Search Strategy
2.4. Selection Process
2.5. Data Extraction
2.6. Methodological Quality Assessment
2.7. Primary-Study Overlap (Corrected Covered Area)
2.8. Synthesis Approach
3. Results
3.1. Search Results and Pool Composition
3.2. Methodological Quality (Results)
3.3. Primary-Study Overlap Analysis
3.4. Implant Survival Outcomes
3.5. Membrane Perforation
3.6. Benign Paroxysmal Positional Vertigo
3.7. Patient-Reported Outcomes
3.8. Biomechanical-Class Synthesis
3.9. Evidence Summary and Main Limitations
4. Discussion
4.1. Principal Findings
4.2. Biomechanical Framework
4.3. Methodological Quality and Evidence Confidence
4.4. Primary-Study Overlap and Cluster-Level CCA
4.5. Clinical Implications
4.6. Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
| Abbreviation | Meaning |
| AMSTAR 2 | A Measurement Tool to Assess Systematic Reviews 2 |
| BPPV | Benign paroxysmal positional vertigo |
| CCA | Corrected Covered Area |
| LSFE/LSFA | Lateral sinus floor elevation/augmentation |
| MBL | Marginal bone loss |
| OD | Osseodensification |
| OMSFE | Osteotome-mediated sinus floor elevation |
| PROMs | Patient-reported outcome measures |
| RBH | Residual bone height |
| SFE | Sinus floor elevation |
| TSFE/TSFA | Transcrestal sinus floor elevation/augmentation |
Appendix A
| Review | Item 2 Protocol | Item 4 Search | Item 7 Excluded Studies | Item 9 Risk of Bias | Item 11 Meta-Analysis | Item 13 RoB in Interpretation | Item 15 Publication Bias | Overall |
|---|---|---|---|---|---|---|---|---|
| Ravidà 2019 [16] | PY | Y | PY | Y | Y | Y | Y | MODERATE |
| Lee 2023 [22] | Y | Y | PY | Y | Y | Y | Y | MODERATE |
| Kadkhodazadeh 2024 [25] | Y | Y | PY | Y | Y | Y | Y | MODERATE |
| Duan 2017 [9] | N | PY | N | PY | Y | PY | N | CRITICALLY LOW |
| Cobo-Vázquez 2025 [26] | Y | PY | N | Y | Y | PY | PY | LOW |
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| First Author, Year [Ref.] | Journal | n | Comparator | Primary Outcome | AMSTAR 2 | |
|---|---|---|---|---|---|---|
| 1 | Duan 2017 [9] | J. Periodontol. | 19 | Graftless TSFA (single-arm) | Implant survival | CRITICALLY LOW |
| 2 | Geminiani 2017 [10] | Quintessence Int. | 28 | TSFA vs. LSFA—complications | Complication rates | CRITICALLY LOW |
| 3 | Chen & Shi 2018 [11] | J. Prosthodont. | 12 | OSFE: graft vs. no-graft | Implant survival; bone gain | LOW |
| 4 | Al-Moraissi 2018 [12] | Clin. Implant Dent. Relat. Res. | 31 | Membrane perforation vs. intact | Implant failure post-perforation | CRITICALLY LOW |
| 5 | Aludden 2018 [13] | Implant Dent. | 9 | LSFA with β-TCP only | Implant survival; bone formation | LOW |
| 6 | Antonoglou 2018 [14] | Int. J. Oral Maxillofac. Implants | 21 | SFA techniques (≥3-yr follow-up) | Implant survival | LOW |
| 7 | Al-Moraissi 2019 [15] | J. Oral Maxillofac. Surg. | 36 | Network MA: SFA techniques (RBH 4–8 mm) | Implant failure | LOW |
| 8 | Ravidà 2019 [16] | Implant Dent. | 19 | Short (≤6 mm) vs. long (≥10 mm) implants | Implant survival; complications | MODERATE |
| 9 | Guo 2020 [17] | Sci. Rep. | 16 | Non-grafted vs. PRF/PRP-grafted TSFE | Implant survival; bone gain | CRITICALLY LOW |
| 10 | Lin 2021 [18] | Int. J. Implant Dent. | 12 | TSFE + short implants (single-arm) | Implant survival | CRITICALLY LOW |
| 11 | Ye 2021 [19] | Int. J. Implant Dent. | 27 | OSFE without graft (single-arm) | Implant survival; bone gain | LOW |
| 12 | Tang 2022 [20] | Int. J. Implant Dent. | 14 | Short (≤8 mm) vs. standard (≥10 mm) implants after SFE | Implant survival; MBL | LOW |
| 13 | Shi QH 2022 [21] | Int. J. Oral Maxillofac. Implants | 23 | TSFA: graft vs. no-graft | Prognostic outcomes | LOW |
| 14 | Lee 2023 [22] | Int. J. Oral Maxillofac. Implants | 38 | Network MA: SFE techniques—perforation | Schneiderian membrane perforation | MODERATE |
| 15 | Potdukhe 2025 [23] | J. Prosthet. Dent. | 11 | Osseodensification vs. osteotome (TSFE) | Implant stability; bone height gain | CRITICALLY LOW |
| 16 | Shi S 2023 [24] | Clin. Oral Implants Res. | 25 | TSFA vs. LSFA at RBH ≤ 6 mm | Implant survival; perforation | MODERATE |
| 17 | Kadkhodazadeh 2024 [25] | Br. J. Oral Maxillofac. Surg. | 17 | TSFE techniques (RCTs) | Implant survival; complications incl. BPPV | MODERATE |
| 18 | Cobo-Vázquez 2025 [26] | Int. J. Implant Dent. | 8 | Osteotome vs. osseodensification (crestal SFE) | Bone height gain; complications | LOW |
| 19 | Starch-Jensen 2025 [27] | J. Oral Maxillofac. Res. | 13 | TSMEOD vs. LSFA/OMSFE | Bone gain; complications; PROMs | LOW |
| 20 | Menini 2025 [28] | Int. J. Oral Maxillofac. Implants | 12 | SFE techniques—PROMs | Patient-reported outcomes | LOW |
| 21 | Schiavo-Di Flaviano 2024 [29] | J. Clin. Med. | 13 | Membrane perforation vs. intact | Implant survival post-perforation | CRITICALLY LOW |
| 22 | Rahate 2023 [30] | J. Indian Soc. Periodontol. | 9 | OSFE simultaneous: graft vs. no-graft | Implant survival; bone height | CRITICALLY LOW |
| 23 | Moraschini 2017 [31] | Int. J. Oral Maxillofac. Surg. | 11 | SFE without graft + simultaneous implant | Implant survival | MODERATE |
| 24 | Shah 2022 [32] | J. Indian Prosthodont. Soc. | 12 | SFE techniques (survival comparison) | Implant survival | CRITICALLY LOW |
| 25 | Mester 2023 [33] | J. Pers. Med. | 10 | Short implants vs. SFE (RCTs ≥5 yr) | Implant survival; MBL | MODERATE |
| 26 | Yan 2019 [34] | BMJ Open | 7 | Short implants (≤6 mm) vs. SFE | Implant survival; complications | MODERATE |
| 27 | Wang M 2022 [35] | Materials (Basel) | 6 | Short implants vs. SFE (RCTs, ≥5 yr post-loading) | Implant survival | CRITICALLY LOW |
| 28 | Raghoebar 2019 [36] | J. Clin. Periodontol. | 87 | LSFE long-term (≥3 yr) | Implant survival | MODERATE |
| 29 | Vetromilla 2021 [4] | J. Prosthet. Dent. | 7 | Short implants vs. SFE (umbrella of 7 SRMAs) | Implant survival; MBL; complications | LOW |
| 30 | Toledano 2022 [5] | Clin. Oral Investig. | 14 | Short implants (≤6 mm) vs. SFE + standard implants (RCTs) | Implant survival; MBL | MODERATE |
| Class | Operational Criterion | Examples | Survival | Complication and PROM Signal | Interpretive Limit |
|---|---|---|---|---|---|
| Impact osteotome | Mallet- or hand-driven osteotome with discrete axial impacts | Summers and related osteotome protocols | Generally 95–100% | BPPV and discomfort reported more often in some reviews; Cobo-Vázquez: 1/24 BPPV (4.17%) in an osteotome group | Sparse events; mixed study designs; no causal inference |
| Drill-based | Rotary preparation or reamer without mallet impact | TSFE reamer and controlled drill protocols | Generally 95–100% | Low perforation ranking in Lee 2023 NMA | Network ranking depends on the included primary studies |
| Hydraulic | Membrane elevation by fluid pressure | Hydraulic elevation devices | Generally 95–100% | Limited technique-specific complication data | No evidence that hydraulic is superior to other subclasses |
| Piezoelectric or ultrasonic | Oscillating tip used for bone preparation or elevation | Piezoelectric and ultrasonic systems | Generally 95–100% | Limited technique-specific data | Few direct comparisons |
| Osseodensification or expansion | Counter-rotating burs or expansion osteotomy without mallet impact | Densah and related expansion protocols | Generally 95–100% | Cobo-Vázquez: overall complications 2.78% OD vs. 14.32% OST; Starch-Jensen reported a BPPV difference | Small OD evidence base; differing denominators; no firm ranking |
| Mixed or unclear | Review combines more than one technique without separable subgroup data | Mixed TSFE reviews | Generally high | Not assigned to one mechanism class | Used only for the relevant clinical question, not for class comparison |
| Outcome | Main Review-Level Evidence | Stronger AMSTAR 2 Anchors | Consistency | Overlap Concern | Main Limit on Interpretation |
|---|---|---|---|---|---|
| Implant survival | Broad evidence across the 30 reviews | Moraschini, Mester, Yan, Ravidà, Raghoebar, Toledano | Generally high across comparisons | Low pool-level overlap; moderate in some clusters | Different clinical questions and follow-up periods |
| Membrane perforation | Reported in several access and technique comparisons | Lee, Shi S, Kadkhodazadeh | Direction varies with comparison | Cluster-dependent | Often mixes transcrestal-vs-lateral and within-TSFE questions |
| BPPV | Reported in a small number of reviews | Kadkhodazadeh; limited support from Cobo-Vázquez and Starch-Jensen | Suggestive osteotome signal | Sparse events | Incomplete denominators and no stable pooled estimate |
| PROMs | One dedicated meta-analysis plus secondary reports | Menini (LOW); selected supportive reviews | Often favours less invasive procedures | Sparse and heterogeneous | Different instruments and time points |
| Short implants vs. SFE | Several RCT-based meta-analyses | Ravidà, Yan, Mester, Toledano | Similar survival; different burdens and complications | Moderate cluster overlap | Implant lengths and augmentation protocols differ |
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Better, H.; Better, K.; Asbi, T.; Lin, S.; Chaushu, G.; Haim, D. An Umbrella Review of Meta-Analyses on Transcrestal Sinus Floor Elevation: Methodological Quality, Primary-Study Overlap, and Interpretive Boundaries. Dent. J. 2026, 14, 483. https://doi.org/10.3390/dj14080483
Better H, Better K, Asbi T, Lin S, Chaushu G, Haim D. An Umbrella Review of Meta-Analyses on Transcrestal Sinus Floor Elevation: Methodological Quality, Primary-Study Overlap, and Interpretive Boundaries. Dentistry Journal. 2026; 14(8):483. https://doi.org/10.3390/dj14080483
Chicago/Turabian StyleBetter, Hadar, Keren Better, Thabet Asbi, Shaul Lin, Gavriel Chaushu, and Doron Haim. 2026. "An Umbrella Review of Meta-Analyses on Transcrestal Sinus Floor Elevation: Methodological Quality, Primary-Study Overlap, and Interpretive Boundaries" Dentistry Journal 14, no. 8: 483. https://doi.org/10.3390/dj14080483
APA StyleBetter, H., Better, K., Asbi, T., Lin, S., Chaushu, G., & Haim, D. (2026). An Umbrella Review of Meta-Analyses on Transcrestal Sinus Floor Elevation: Methodological Quality, Primary-Study Overlap, and Interpretive Boundaries. Dentistry Journal, 14(8), 483. https://doi.org/10.3390/dj14080483

