A Systematic Review of Stem Cell Applications in Maxillofacial Regeneration
Abstract
:1. Introduction
2. Methods
3. Results
3.1. Safety and Efficacy of Stem Cell Therapy
3.2. Bone Regeneration and Quality
3.3. Risk of Bias Assessment
3.4. Limitations of Included Studies
4. Discussion
4.1. Safety and Immune Modulation
4.2. Efficacy and Quality of Regenerated Bone
4.3. Clinical Implications and Future Directions
4.4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Inclusion Criteria | Exclusion Criteria |
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Databases Database Link Search Date | Search Strategies | Number of Articles Found |
---|---|---|
Scopus https://www.scopus.com/home.uri (accessed on 2 February 2024) | (TITLE-ABS-KEY (“stem cell*”) AND TITLE-ABS-KEY (“bone regeneration” OR “tissue regeneration” OR “tissue engineering” OR “bone graft*”) AND TITLE-ABS-KEY (dent*)) AND PUBYEAR > 2013 AND PUBYEAR < 2023 AND (EXCLUDE (EXACTKEYWORD, “Animals”) OR EXCLUDE (EXACTKEYWORD, “Nonhuman”) OR EXCLUDE (EXACTKEYWORD, “Animal”) OR EXCLUDE (EXACTKEYWORD, “Animal Experiment”) OR EXCLUDE (EXACTKEYWORD, “Mouse”) OR EXCLUDE (EXACTKEYWORD, “Animal Tissue”) OR EXCLUDE (EXACTKEYWORD, “Animal Cell”) OR EXCLUDE (EXACTKEYWORD, “Rat”) OR EXCLUDE (EXACTKEYWORD, “Mice”) OR EXCLUDE (EXACTKEYWORD, “Animal Model”) OR EXCLUDE (EXACTKEYWORD, “Rats”)) | 1897 |
PubMed https://pubmed.ncbi.nlm.nih.gov (accessed on 2 February 2024) | ((“stem cell*” [Title/Abstract]) AND (“bone regeneration” [Title/Abstract] OR “tissue regeneration” [Title/Abstract] OR “tissue engineering” [Title/Abstract] OR “bone graft*” [Title/Abstract]) AND “dent*” [Title/Abstract]) AND ((humans[Filter]) | 980 |
WoS https://access.clarivate.com/login?app=wos (accessed on 2 February 2024) | ((TS = (“stem cell*”)) AND TS = (“bone regeneration” OR “tissue regeneration” OR “tissue engineering” OR “bone graft*”)) AND TS = (dent*) AND ((ALL = ((“population groups” not “animal models”))) OR ALL = (men OR women OR patient OR female OR male OR subjects OR adult)) NOT ALL = (“animal models”) AND (PY = (“2023” OR “2022” OR “2021” OR “2020” OR “2019” OR “2018” OR “2017” OR “2016” OR “2015” OR “2014” OR “2013”)) | 488 |
OVID https://ovidsp.ovid.com/ (accessed on 2 February 2024) | ((stem cell*.ti,ab) AND ((bone regeneration.ti,ab) OR (tissue regeneration.ti,ab) OR (tissue engineering.ti,ab) OR (bone graft*.ti,ab)) AND (dent*.ti,ab) AND ((men) OR (women) OR (patient) OR (female) OR (male) OR (subjects) OR (adult)) NOT (animal models)) limit to yr = “2013–2023” | 108 |
Cochrane Library https://www.cochranelibrary.com/advanced-search (accessed on 2 February 2024) | Title Abstract Keyword—((stem cell*) AND ((bone regeneration) OR (tissue regeneration) OR (tissue engineering) OR (bone graft *)) AND (dent*) AND ((men) OR (women) OR (patient) OR (female) OR (male) OR (subjects) OR (adult)) NOT (animal models)) | 65 |
Dentistry & Oral Sciences Source—Ebscohost https://www.ebsco.com/products/research-databases/dentistry-oral-sciences-source (accessed on 2 February 2024) | TI(((stem cell*) AND ((bone regeneration) OR (tissue regeneration) OR (tissue engineering) OR (bone graft*)) AND (dent*))) AND AB(((stem cell*) AND ((bone regeneration) OR (tissue regeneration) OR (tissue engineering) OR (bone graft*)) AND (dent*))) AND ((men) OR (women) OR (patient) OR (female) OR (male) OR (subjects) OR (adult)) NOT (animal models) | 2 |
Author (Year) | Country | Study Aim | Study Design | Stem Cell Type | Dental Surgical Procedures | Outcomes |
---|---|---|---|---|---|---|
Asahina et al. (2021) [20] | Japan | Examine the safety and efficacy of bone tissue engineering for patients with a severely atrophic alveolar bone | Cohort study | Bone marrow stem cells | Sinus lift | During treatment and follow-ups for 66 months, no side effects or health concerns were noted. Therapy was safe and effective. |
Feng et al. (2021) [21] | Taiwan | Assess safety and efficacy of regeneration in the case of large bony defects | Phase I study | Small blood stem cells | Various types | All implants were implanted successfully. Elevated levels of eotaxin, fibroblast growth factor, monocyte chemoattractant protein 1, macrophage-derived chemokine, and interleukin-17A found in patients after small blood cell treatment. |
Giuliani et al. (2013) [24] | Italy | Assess the stability and quality of regenerated bone and vessel network | Cohort study | Dental pulp stem cells | Bone graft | Three years after grafting in the mandible, the regenerated bone was uniformly vascularized and exhibited a compact structure, rather than a cancellous one. |
Gjerde et al. (2018) [25] | Norway | Evaluate bone regeneration using marrow-derived mesenchymal stromal cells | Clinical Trial | Bone marrow-derived stromal cells | Sinus augmentation | The bone marrow cells induced significant new bone formation. |
Gupta et al. (2021) [26] | India | Evaluate quality and quantity of bone formation in maxillary sinus lift and implant stability of atrophic maxilla | Case–control | Mesenchymal stem cells | Sinus augmentation | Of the 40 sinus lifts performed and 42 implants placed, all showed primary stability. |
Katagiri et al. (2016) [22] | Japan | Examine safety and osteogenic potential of mesenchymal stem cells in bone | Case–control | Mesenchymal stem cells | Bone graft | Bone marrow-derived mesenchymal stem cells were used safely with less inflammation and showed great osteogenic potential. |
Katagiri et al. (2017) [23] | Japan | Evaluate safety of secretome of bone marrow-derived mesenchymal stem cells for maxillary sinus lift | Case–control | Mesenchymal stem cells | Bone graft | Bone formation was clinically confirmed in all cases. The secretome of bone marrow-derived mesenchymal stem cells was used safely. |
Author (Year) | Selection Bias a | Performance Bias b | Detection Bias c | Attrition Bias d | Reporting Bias e | Other Bias f | Overall Risk of Bias g |
---|---|---|---|---|---|---|---|
Asahina et al. (2021) [20] | Low | High | Low | Low | Low | Medium | Moderate |
Feng et al. (2021) [21] | Medium | High | Medium | Medium | Low | High | High |
Giuliani et al. (2013) [24] | Low | Medium | Low | Medium | Medium | Medium | Moderate |
Gjerde et al. (2018) [25] | Medium | High | Medium | High | Medium | Low | High |
Gupta et al. (2021) [26] | Low | Medium | Low | Low | Low | Low | Low |
Katagiri et al. (2016) [22] | High | High | High | Medium | High | Medium | High |
Katagiri et al. (2017) [23] | High | High | Medium | Medium | Medium | Medium | High |
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Hung, M.; Sadri, M.; Katz, M.; Schwartz, C.; Mohajeri, A. A Systematic Review of Stem Cell Applications in Maxillofacial Regeneration. Dent. J. 2024, 12, 315. https://doi.org/10.3390/dj12100315
Hung M, Sadri M, Katz M, Schwartz C, Mohajeri A. A Systematic Review of Stem Cell Applications in Maxillofacial Regeneration. Dentistry Journal. 2024; 12(10):315. https://doi.org/10.3390/dj12100315
Chicago/Turabian StyleHung, Man, Mahsa Sadri, Melanie Katz, Connor Schwartz, and Amir Mohajeri. 2024. "A Systematic Review of Stem Cell Applications in Maxillofacial Regeneration" Dentistry Journal 12, no. 10: 315. https://doi.org/10.3390/dj12100315