Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma
Abstract
:1. Introduction
2. Search and Review Strategies
3. Histopathological Pattern and ACC Prognosis
4. Individual Histological Features and ACC Prognosis
5. Histopathological Grading Systems for ACC
6. Future Directions
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Authors | Year | Sample Size | Follow-Up in Months, Mean (Range) | Histopathological Parameter or Grading System | Survival | |
---|---|---|---|---|---|---|
Univariable Significance | Multivariable Significance | |||||
Bjørndal et al. [40] | 2015 | 201 | 91 (4–240) | Positive/close margin | Yes | Yes |
Perzin–Szanto system | Yes | Yes | ||||
van Weert et al. [14] | 2015 | 87 | NI | Perzin–Szanto system | Yes | Yes |
Spiro system | Yes | Yes | ||||
Van Weert system | Yes | Yes | ||||
Han et al. [41] | 2017 | 54 | 68 (16–120) | PNI | Yes | No |
Perzin–Szanto system | Yes | No | ||||
Ouyang et al. [42] | 2017 | 228 | 74.6 (12–288) | LVI | Yes | Yes |
PNI | Yes | No | ||||
Positive/close margin | Yes | Yes | ||||
Ouyang et al. [43] | 2017 | 120 | 60.5 (2–288) | LVI | Yes | Yes |
PNI | Yes | No | ||||
Perzin–Szanto system | Yes | No | ||||
Xu et al. [19] | 2017 | 135 | 75 (1–353) | Perzin–Szanto system | Yes | Yes |
Lim et al. [44] | 2018 | 52 | 72 (5–152) | LVI | Yes | Yes |
PNI | No | No | ||||
Perzin–Szanto system | Yes | Yes | ||||
Zhang et al. [45] | 2019 | 158 | 83.7 (3.5–140) | PNI | Yes | Yes |
Akbaba et al. [46] | 2020 | 207 | 50 (3–121) | PNI | No | No |
Perzin–Szanto system | Yes | Yes | ||||
Kawakita et al. [47] | 2020 | 192 | 65 (5–245) | Positive/close margin | Yes | Yes |
Van Weert system | Yes | Yes | ||||
Morita et al. [15] | 2021 | 195 | 52 (1–263) | Positive/close margin | Yes | Yes |
PNI | No | No | ||||
Perzin–Szanto system | Yes | Yes | ||||
Spiro system | Yes | Yes | ||||
Van Weert system | Yes | Yes | ||||
MinAmax system | Yes | Yes |
Grading System | Description | ||
---|---|---|---|
Spiro system [16] | Grade I: typical cribriform pattern exclusively. | Grade II: mixed with substantial solid component. | Grade III: tumors formed mainly by solid areas or with areas of clear anaplasia. |
Perzin–Szanto system [17,18] | Grade I: tumors with tubular and cribriform areas, but without solid component. | Grade II: cribriform tumors that were either pure or mixed with <30% of solid areas. | Grade III: tumors with solid component >30%. |
van Weert system [14] | Low grade: tumors with absence of solid component (S−). | High grade: tumors with solid areas (S+). | |
MinAmax system [15] | Low grade: tumors with complete lack of solid areas or solid areas with diameter ≤0.20 mm. | High grade: tumors with solid nests with diameter >0.20 mm. |
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de Morais, E.F.; de Farias Morais, H.G.; de Almeida Freitas, R.; Coletta, R.D. Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma. Dent. J. 2023, 11, 262. https://doi.org/10.3390/dj11110262
de Morais EF, de Farias Morais HG, de Almeida Freitas R, Coletta RD. Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma. Dentistry Journal. 2023; 11(11):262. https://doi.org/10.3390/dj11110262
Chicago/Turabian Stylede Morais, Everton Freitas, Hannah Gil de Farias Morais, Roseana de Almeida Freitas, and Ricardo D. Coletta. 2023. "Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma" Dentistry Journal 11, no. 11: 262. https://doi.org/10.3390/dj11110262
APA Stylede Morais, E. F., de Farias Morais, H. G., de Almeida Freitas, R., & Coletta, R. D. (2023). Prognostic Significance of Histopathological Parameters for Salivary Gland Adenoid Cystic Carcinoma. Dentistry Journal, 11(11), 262. https://doi.org/10.3390/dj11110262