Effect of Endodontic Irrigating Solutions on Radicular Dentine Structure and Matrix Metalloproteinases—A Comprehensive Review
Abstract
:1. Introduction
2. Effects of Irrigating Solutions on Dentin Structure
2.1. Effect of Sodium Hypochlorite
2.2. Effect of Decalcifying Agents
2.3. Effect of Chlorhexidine
3. Effect of Combined Irrigating Solutions on Dentin
4. Effect of Irrigating Solutions on Endogenous Matrix Metalloproteinases (MMPs)
5. Final Remarks and Future Research Directions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Irrigating Solutions | |||
---|---|---|---|
NaOCl | EDTA | CHX | |
General considerations | |||
pH range | 11–13 | 7–9 | 5–7 |
Concentrations | 0.5–10% | 1–17% | 0.12–2% |
Biocompatibility | Low | Low | High |
Mode of action | Bactericidal | Bacteriostatic | Bacteriostatic |
Substantivity | Low | Low | High |
Tissue dissolution | High ** | Low | Low |
Smear layer removal | Low | High | Low |
Effect on dentin’s composition | |||
Collagen degradation | Medium ** | High + | Low |
Carbonate/phosphate ratio | Decrease * | Decrease | Low |
Effect on dentin’s physical and mechanical properties | |||
Microhardness | Reduce | Reduce | No effect |
Erosion | High ++ | High ++ | No effect |
Surface roughness | Increase | Increase | No effect |
Bond strength | Reduce | Reduce | Increase |
Retana-Lobo et al., 2021 [36] | Baruwa et al., 2022 [37] | |
---|---|---|
Methodological aspects | ||
Methodology for assessing MMP activity | Gelatin zymography of dentine powder. | In situ zymography of the hybrid layer. |
Irrigating solutions used | Distilled water, 5% NaOCl, 18% EDTA, 2% CHX | Saline, 5.25% NaOCl, 10% Citric acid, 0.2% CHX |
Sample size | 20 single roots (n = 5) | 24 single roots (n = 6) |
Most relevant findings | ||
NaOCl effect on MMPs | Reduced | Reduced |
Combination of NaOCl + EDTA/CA effect on MMPs | Increased | Increased |
NaOCl + EDTA/CA + CHX effect on MMPs | Reduced | Reduced |
Correlation of MMP activity with root bond strength | N/A | Yes |
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Baruwa, A.O.; Martins, J.N.R.; Maravic, T.; Mazzitelli, C.; Mazzoni, A.; Ginjeira, A. Effect of Endodontic Irrigating Solutions on Radicular Dentine Structure and Matrix Metalloproteinases—A Comprehensive Review. Dent. J. 2022, 10, 219. https://doi.org/10.3390/dj10120219
Baruwa AO, Martins JNR, Maravic T, Mazzitelli C, Mazzoni A, Ginjeira A. Effect of Endodontic Irrigating Solutions on Radicular Dentine Structure and Matrix Metalloproteinases—A Comprehensive Review. Dentistry Journal. 2022; 10(12):219. https://doi.org/10.3390/dj10120219
Chicago/Turabian StyleBaruwa, Abayomi Omokeji, Jorge N. R. Martins, Tatjana Maravic, Claudia Mazzitelli, Annalisa Mazzoni, and António Ginjeira. 2022. "Effect of Endodontic Irrigating Solutions on Radicular Dentine Structure and Matrix Metalloproteinases—A Comprehensive Review" Dentistry Journal 10, no. 12: 219. https://doi.org/10.3390/dj10120219