SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Clinicopathologic Findings
3.2. SATB2 Status
3.3. MDM2 Status
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Case No. | Age | Sex | Location | Size (cm) | SATB2 IHC | MDM2 IHC | MDM2 FISH |
---|---|---|---|---|---|---|---|
1 | 49 | M | Mandible | 5 | Positive | Positive | Failed |
2 | 19 | F | Mandible | 10 | Positive | Positive | Failed |
3 | 16 | M | Mandible | NA | Positive | Positive, focal | Failed |
4 | 35 | F | Mandible | 9.5 | Positive | Negative | Failed |
5 | 35 | M | Maxilla | 10 | Positive | Negative | Failed |
6 | 23 | F | Maxilla | 5 | Positive | Negative | Failed |
7 | 10 | M | Mandible | 6.5 | Positive | Negative | Failed |
8 | 42 | F | Maxilla | 12 | Positive | Negative | Failed |
9 | 17 | F | Mandible | 16 | Positive | Negative | Failed |
10 | 42 | F | Maxilla | 5 | Positive | Negative | No amplification |
11 | 31 | M | Mandible | 12 | Positive | Negative | No amplification |
Diagnosis | No. of Cases | No. (%) of Cases Positive for SATB2 | No. (%) of Cases Positive for MDM2 | ||||||
---|---|---|---|---|---|---|---|---|---|
Score 0 | Score 1 | Score 2 | Score 3 | Score 0 | Score 1 | Score 2 | Score 3 | ||
Chondroblastic OSJ | 5 | 0 | 1 (20) | 2 (40) | 2 (40) | 4 (80) | 1 (20) | 0 | 0 |
Osteoblastic OSJ | 3 | 0 | 0 | 0 | 3 (100) | 2 (67) | 1 (33) | 0 | 0 |
Fibroblastic OSJ | 2 | 0 | 0 | 1 (50) | 1 (50) | 1 (50) | 1 (50) | 0 | 0 |
Small-cell OSJ | 1 | 0 | 0 | 1 (100) | 0 | 1 (100) | 0 | 0 | 0 |
Ewing sarcoma | 1 | 1 (100) | 0 | 0 | 0 | 1 (100) | 0 | 0 | 0 |
Ossifying fibroma | 7 | 0 | 3 (43) | 2 (28) | 2 (28) | 7 (100) | 0 | 0 | 0 |
Fibrous dysplasia | 5 | 0 | 4 (80) | 1 (20) | 0 | 5 (100) | 0 | 0 | 0 |
Articles | SATB2 IHC | MDM2 IHC |
---|---|---|
Grad-Akrish et al. [30] | 15/15 (100%) all moderate or strong diffuse | NP |
Lott Limbach et al. [32] | NP | 7/11 (63%; all weak focal) |
Guerin et al. [21] | NP | 3/36 (8%) |
Lopes et al. [33] | NP | 8/9 (89%) |
Junior et al. [34] | NP | 6/25 (24%) |
Owosho et al. (current) | 11/11 (100%) all strong diffuse | 3/11 (27%; two moderate diffuse, one weak focal) |
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Owosho, A.A.; Ladeji, A.M.; Adesina, O.M.; Adebiyi, K.E.; Olajide, M.A.; Okunade, T.; Palmer, J.; Kehinde, T.; Vos, J.A.; Cole, G.; et al. SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw. Dent. J. 2022, 10, 4. https://doi.org/10.3390/dj10010004
Owosho AA, Ladeji AM, Adesina OM, Adebiyi KE, Olajide MA, Okunade T, Palmer J, Kehinde T, Vos JA, Cole G, et al. SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw. Dentistry Journal. 2022; 10(1):4. https://doi.org/10.3390/dj10010004
Chicago/Turabian StyleOwosho, Adepitan A., Adeola M. Ladeji, Olufunlola M. Adesina, Kehinde E. Adebiyi, Mofoluwaso A. Olajide, Toluwaniyin Okunade, Jacob Palmer, Temitope Kehinde, Jeffrey A. Vos, Grayson Cole, and et al. 2022. "SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw" Dentistry Journal 10, no. 1: 4. https://doi.org/10.3390/dj10010004
APA StyleOwosho, A. A., Ladeji, A. M., Adesina, O. M., Adebiyi, K. E., Olajide, M. A., Okunade, T., Palmer, J., Kehinde, T., Vos, J. A., Cole, G., & Summersgill, K. F. (2022). SATB2 and MDM2 Immunoexpression and Diagnostic Role in Primary Osteosarcomas of the Jaw. Dentistry Journal, 10(1), 4. https://doi.org/10.3390/dj10010004