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Open AccessArticle

On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes

Institute of Inorganic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany
Author to whom correspondence should be addressed.
Inorganics 2019, 7(7), 91;
Received: 26 June 2019 / Revised: 12 July 2019 / Accepted: 16 July 2019 / Published: 22 July 2019
(This article belongs to the Special Issue Metal Complexes Containing Boron Based Ligands)
3,1,2-Ruthenadicarbadodecaborane complexes bearing the [C2B9H11]2− (dicarbollide) ligand are robust scaffolds, with exceptional thermal and chemical stability. Our previous work has shown that these complexes possess promising anti-tumor activities in vitro, and tend to form aggregates (or self-assemblies) in aqueous solutions. Here, we report on the synthesis and characterization of four ruthenium(II) complexes of the type [3-(η6-arene)-1,2-R2-3,1,2-RuC2B9H9], bearing either non-polar (R = Me (24)) or polar (R = CO2Me (7)) substituents at the cluster carbon atoms. The behavior in aqueous solution of complexes 2, 7 and the parent unsubstituted [3-(η6-p-cymene)-3,1,2-RuC2B9H11] (8) was investigated via UV-Vis spectroscopy, mass spectrometry and nanoparticle tracking analysis (NTA). All complexes showed spontaneous formation of self-assemblies (108–109 particles mL−1), at low micromolar concentration, with high polydispersity. For perspective applications in medicine, there is thus a strong need for further characterization of the spontaneous self-assembly behavior in aqueous solutions for the class of neutral metallacarboranes, with the ultimate scope of finding the optimal conditions for exploiting this self-assembling behavior for improved biological performance. View Full-Text
Keywords: metallacarborane; ruthenium; aggregation; UV-Vis spectroscopy; NTA metallacarborane; ruthenium; aggregation; UV-Vis spectroscopy; NTA
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MDPI and ACS Style

Gozzi, M.; Schwarze, B.; Coburger, P.; Hey-Hawkins, E. On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes. Inorganics 2019, 7, 91.

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