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Responsive ParaCEST Contrast Agents

Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d’Orléans, rue Charles Sadron, CS 80054, 45071 Orléans CEDEX 2, France
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Inorganics 2019, 7(5), 68; https://doi.org/10.3390/inorganics7050068
Received: 2 May 2019 / Revised: 16 May 2019 / Accepted: 21 May 2019 / Published: 25 May 2019
(This article belongs to the Special Issue MRI Contrast Agents)
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Abstract

This article aimed at reviewing the advances on the development of paramagnetic complexes used as chemical exchange saturation transfer agents in magnetic resonance imaging. This relatively new type of contrast opens new avenues in the development of MRI probes for molecular imaging, and coordination chemistry lies at the center of such advances. Strategies to detect important biomarkers such as pH, cations, anions, metabolites, enzyme, and O2 were described. The current challenges, limitations, and opportunities in this field of research were discussed. View Full-Text
Keywords: molecular imaging; MRI; contrast agents; chemical exchange saturation transfer; lanthanides; transition metal ions molecular imaging; MRI; contrast agents; chemical exchange saturation transfer; lanthanides; transition metal ions
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Tóth, É.; Bonnet, C.S. Responsive ParaCEST Contrast Agents. Inorganics 2019, 7, 68.

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