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Article

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

1
Faculty of Physics, Lomonosov Moscow State University, Leninskie Gory 1, 119991 Moscow, Russia
2
Institute of Applied Physics Russian Academy of Sciences, Uljanov St. 46, 603950 Nizhny Novgorod, Russia
3
Privolzhsky Research Medical University, Minin and Pozharsky Sq. 10/1, 603950 Nizhny Novgorod, Russia
4
Institute of Information Technology, Mathematics and Mechanics, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Av., 603950 Nizhny Novgorod, Russia
*
Author to whom correspondence should be addressed.
Photonics 2021, 8(12), 580; https://doi.org/10.3390/photonics8120580
Received: 3 November 2021 / Revised: 4 December 2021 / Accepted: 11 December 2021 / Published: 15 December 2021
(This article belongs to the Special Issue Topical Problems of Biophotonics)
Biodegradable and low-toxic silicon nanoparticles (SiNPs) have potential in different biomedical applications. Previous experimental studies revealed the efficiency of some types of SiNPs in tumor hyperthermia. To analyse the feasibility of employing SiNPs produced by the laser ablation of silicon nanowire arrays in water and ethanol as agents for laser tumor hyperthermia, we numerically simulated effects of heating a millimeter-size nodal basal-cell carcinoma with embedded nanoparticles by continuous-wave laser radiation at 633 nm. Based on scanning electron microscopy data for the synthesized SiNPs size distributions, we used Mie theory to calculate their optical properties and carried out Monte Carlo simulations of light absorption inside the tumor, with and without the embedded nanoparticles, followed by an evaluation of local temperature increase based on the bioheat transfer equation. Given the same mass concentration, SiNPs obtained by the laser ablation of silicon nanowires in ethanol (eSiNPs) are characterized by smaller absorption and scattering coefficients compared to those synthesized in water (wSiNPs). In contrast, wSiNPs embedded in the tumor provide a lower overall temperature increase than eSiNPs due to the effect of shielding the laser irradiation by the highly absorbing wSiNPs-containing region at the top of the tumor. Effective tumor hyperthermia (temperature increase above 42 °C) can be performed with eSiNPs at nanoparticle mass concentrations of 3 mg/mL and higher, provided that the neighboring healthy tissues remain underheated at the applied irradiation power. The use of a laser beam with the diameter fitting the size of the tumor allows to obtain a higher temperature contrast between the tumor and surrounding normal tissues compared to the case when the beam diameter exceeds the tumor size at the comparable power. View Full-Text
Keywords: pulsed laser ablation in a liquid; light scattering; Monte Carlo technique; finite elements method; hyperthermia; bioheat transfer equation pulsed laser ablation in a liquid; light scattering; Monte Carlo technique; finite elements method; hyperthermia; bioheat transfer equation
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MDPI and ACS Style

Sokolovskaya, O.I.; Sergeeva, E.A.; Golovan, L.A.; Kashkarov, P.K.; Khilov, A.V.; Kurakina, D.A.; Orlinskaya, N.Y.; Zabotnov, S.V.; Kirillin, M.Y. Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles. Photonics 2021, 8, 580. https://doi.org/10.3390/photonics8120580

AMA Style

Sokolovskaya OI, Sergeeva EA, Golovan LA, Kashkarov PK, Khilov AV, Kurakina DA, Orlinskaya NY, Zabotnov SV, Kirillin MY. Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles. Photonics. 2021; 8(12):580. https://doi.org/10.3390/photonics8120580

Chicago/Turabian Style

Sokolovskaya, Olga I., Ekaterina A. Sergeeva, Leonid A. Golovan, Pavel K. Kashkarov, Aleksandr V. Khilov, Daria A. Kurakina, Natalia Y. Orlinskaya, Stanislav V. Zabotnov, and Mikhail Y. Kirillin. 2021. "Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles" Photonics 8, no. 12: 580. https://doi.org/10.3390/photonics8120580

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